健康研究2016，Vol.36Issue(6)：647-648,651,3.DOI:10.3969/j.issn.1674-6449.2016.06.015
氧化应激与帕金森老年患者运动功能的关系
Effect of oxidative stress on the physical activity of elderly patients of Parkinson's disease
万珠琴 1钱文光 1管晓斌1
作者信息
- 1. 乐清市第二人民医院 神经内科，浙江 乐清325608
- 折叠
摘要
Abstract
Objective To explore the effect of oxidative stress on the physical activity of elderly patients with Parkinson 's disease.Method 50 patients with Parkinson's disease (experimental group) and 50 healthy persons (control group) were chosen as the subjects of study .The serum trace element and plasma levels of indicators related to oxidative stress in the control group and different Hoehn-Yahr(H-Y)grades, including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione ( GSH) were detected and then the index patient relationship with its live Hoehn-Yahr grade between the experimental group was observed .Findings The serum copper and the average content of zinc of the control group were statistically higher than those of the experimental group .The lead level in the control group was statistically lower than that of the experimental group .The average content of MDA in plasma of the control group was statistically lower than that of the experimental group .SOD in plasma and the average content of GSH of the control group were statistically higher than those of the experimental group.The differences were statistically significant (P<0.05).The experimental group was found to include 8 cases of H-Y1, 13 cases of H-Y2 13, 17 cases of H-Y3, and 12 cases with HY≥4 12 .In patients with Hoehn-Yahr classification and plasma the MAD content was significantly positively correlated with SOD while the GSH content was significantly negatively correlated ( P <0.05 ).Conclusion With the development of the disease , the ability of anti oxidative stress in patients with Parkinson's disease is getting worse and worse .关键词
氧化应激/帕金森病症/运动Key words
oxidative stress/Parkinson's disease/physical activity分类
医药卫生引用本文复制引用
万珠琴,钱文光,管晓斌..氧化应激与帕金森老年患者运动功能的关系[J].健康研究,2016,36(6):647-648,651,3.
