检验医学与临床2016，Vol.13Issue(24)：3453-3455,3.DOI:10.3969/j.issn.1672-9455.2016.24.007
沙利度胺在局部晚期非小细胞肺癌中抗血管生成作用的研究
Study on anti-angiogenesis effect of thalidomide in locally advanced non-small cell lung cancer
摘要
Abstract
Objective To investigate the anti‐angiogenic effects of thalidomide in the treatment of locally advanced non‐small cell lung cancer .Methods A total of 40 patients with locally advanced non‐small cell lung cancer from October 2012 to January 2014 were enrolled in the study .The patients were divided into control group (concurrent chemotherapy alone) and treatment group (on the basis of the control group ,combined with thalidomide) ,20 cases in each group .Synchronous radiation dose 60 Gy/6 ,30 times a week ;chemotherapy for the PC (paclitaxel 45-50 mg/m2 weekly+carboplatin AUC=2 weekly)/EP (cisplatin 50 mg/m2 D1 ,8 , 29 ,36+VP16 50 mg/m2 D1-5 ,D29 -33);Thalidomide daily 200 mg orally ,first days for 10 weeks .Serum vascular endothelial growth factor (VEGF) levels in all patients were detected by enzyme‐linked immunosorbent assay (ELISA) in 6 ,10 and 0 weeks . Results At the 10th week after treatment ,the level of VEGF in the treatment group[(220 .35 ± 82 .61) pg/mL] was significantly lower than that in the control group[(292 .76 ± 152 .06) pg/mL](P<0 .05) .The short‐term curative effect of the treatment group (55% ) was higher than that of the control group (40% ) ,but the difference was not statistically significant (P>0 .05) .In the treat‐ment group ,the sleep improvement ,body weight increase ,appetite increase and pain relief were better than the control group ,and the differences were statistically significant (P<0 .05) .The control group benefited 4 cases ,the treatment group benefited 17 ca‐ses ,the difference was statistically significant (χ2 =16 .942 ,P=0 .000) .There was no statistically significant difference between non‐hematologic toxicity and hematologic toxicity in the control and treatment groups (P>0 .05) .Conclusion Thalidomide com‐bined with EP/PC regimen concurrent chemoradiotherapy can significantly decrease the serum level of VEGF ,improve the local ad‐vanced non small cell lung cancer patients with clinical benefit rate ,without increasing side effects .关键词
沙利度胺/局部晚期非小细胞肺癌/抗血管生成/血管内皮细胞生长因子Key words
sthalidomide/non-small cell lung cancer/anti-angiogenic/vascular endothelial grow th factor引用本文复制引用
李爱科,杜新生,庞德全,王东娟,李青山,刘艳丽,林萍萍,朱翠敏..沙利度胺在局部晚期非小细胞肺癌中抗血管生成作用的研究[J].检验医学与临床,2016,13(24):3453-3455,3.基金项目
河北省承德市科学技术研究与发展计划资助项目（20142067）。 （）
