河南科技大学学报（医学版）2016，Vol.34Issue(4)：241-243,3.DOI:10.15926/j.cnki.issn1672-688x.2016.04.001
山茱萸果核水溶性成分对实验性心律失常的影响
Effects of Fructus Corni Fruit Core Water-Soluble Components on Experimental Arrhythmia
摘要
Abstract
Objective To study the effect of Fructus Corni fruit core water-soluble components on electrocardiogram( ECG) of experimental arrhythmia model. Methods The healthy Kunming mice and SD rats were randomly divided into control group,positive drug group,low and high dosage of the water-soluble constituents of Fructus Corni fruit core with drug intragastric administration once a day for 5days. ECG was recorded among different arrhythmia induced by CaCl2 , chloroform and aconitine in each group. Results①Latency of mouse ventricular fibrillation induced by calcium chloride were extended in the core of high dose group (2. 37 ± 0. 09) s , and the duration of ventricular arrhythmia were shortened(150. 9 ± 51. 2) s, so there were statistically significant compared with the model group ( all P < 0 . 05 ) . ②The ventricular fibrillation ratio of Fructus Corni fruit core water-soluble components in high dose group decreased in mice induced by chloroform compared with the control group(P<0. 05).③The latency of VE(8. 20 ± 0. 84) s, VT(112. 00 ± 6. 60) s, VF(19. 5 ± 1. 29) s and CA(54. 32 ± 10. 20) s were prolonged in high-dose group ( P <0 . 05 ) . Conclusion Fructus Corni fruit core water-soluble components had a protective effect on arrhythmia model by CaCl2 , chloroform and aconitine. The mechanism might be related to sodium channel blockade, calcium channel blockade and the body′s sensitivity of catecholamine reduced.关键词
山茱萸果核水溶性成分/心律失常/小鼠/氯化钙/乌头碱Key words
Fructus Corni/arrhythmia/mice/calcium chloride/aconitine分类
医药卫生引用本文复制引用
李永瑞,周培源,李艳..山茱萸果核水溶性成分对实验性心律失常的影响[J].河南科技大学学报（医学版）,2016,34(4):241-243,3.基金项目
河南省科技厅科技攻关项目(082102310031) （082102310031）
