河南科技大学学报（医学版）2016，Vol.34Issue(4)：255-258,4.DOI:10.15926/j.cnki.issn1672-688x.2016.04.005
TTN、ALK、MUC2高频变异位点与胃癌临床病理特征的相关性
Correlation between TTN,ALK,MUC2 Recurrent Mutation Sites and Clinicopathologic Characteristics in Gastric Cancer
王珍珍 1王公平 1张伟 1裴哲1
作者信息
- 1. 河南科技大学临床医学院，河南科技大学第一附属医院，河南洛阳471003
- 折叠
摘要
Abstract
Objective To study the recurrent mutation sites in gastric cancer and explore its relation to clinicopathologic significance of gastric cancer. Methods New generation sequencing was applied to 26 cases of gastric cancer tissues by the targeted deep sequencing. The sequencing data were compared with UCSC hg19 database, and the recurrent mutation sites were screened and analyzed with the clinicopathologic features of gastric cancer. Results The recurrent mutation sites in gastric cancer were TTN rs12693166 (15/26), TTN rs2627043(22/26), ALK rs3795850(19/26), ALK rs1881420(23/26), MUC2 rs2856111 (20/26 ) , MUC2 rs56365200 ( 20/26 ) . There were no statistical significance between these recurrent mutation sites and the clinicopathological features in patients with gastric cancer. Conclusion The recurrent mutation sites ( TTN rs12693166 , rs2627043 , ALK rs3795850 , rs1881420 , MUC2 rs2856111 , rs56365200) might be correlated with the carcinogenesis of gastric cancer. No significant association were found between these recurrent mutation sites and the clinicopathological features in patients with gastric cancer.关键词
胃癌/测序分析/高频变异位点/临床病理特征Key words
gastric cancer/sequencing analysis/recurrent mutation sites/clinicopathological characteristics分类
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王珍珍,王公平,张伟,裴哲..TTN、ALK、MUC2高频变异位点与胃癌临床病理特征的相关性[J].河南科技大学学报（医学版）,2016,34(4):255-258,4.
