中国医疗设备2016，Vol.31Issue(12)：10-16,7.DOI:10.3969/j.issn.1674-1633.2016.12.003
脑年龄估值差对健康老龄大脑认知储备的定量分析
Quantitative Analysis of Cognitive Reserve of the Healthy Elder Brain Based on BrainAGE
摘要
Abstract
Cognitive reserve interprets individual differences in susceptibility to deterioration of cognitive functions in the dementia and other brain degradation of brain substance. Traditionally, cognitive reserve is estimated indirectly by measuring static proxy variables. Imaging studies have shown that subjects with neurodegenerative disease have higher brain age gap estimation (BrainAGE) scores due to advanced brain ageing. The present study extends BrainAGE to evaluate cognitive reserve on a cohort of 72 healthy older adults who underwent several neuropsychological tests and structural magnetic resonance imaging (MRI). The result showed that people with lower BrainAGE scores are more resilient than others. These suggest that changes in BrainAGE may capture how brain network dynamicaly adapts itself to compensate brain damage, and BrainAGE could be an alternative proxy for cognitive reserve than other static cognitive reserve proxies.关键词
认知储备/脑连接组/大脑年龄估值差/弥散张量成像Key words
cognitive reserve/connectome/BrainAGE/diffusion tensor imaging分类
医药卫生引用本文复制引用
林岚,张柏雯,吴水才..脑年龄估值差对健康老龄大脑认知储备的定量分析[J].中国医疗设备,2016,31(12):10-16,7.基金项目
国家科技支撑计划课题（2015BAI02B03）；北京市自然科学基金资助项目（7143171）。 （）
