应用化学2016，Vol.33Issue(12)：1383-1388,6.DOI:10.11944/j.issn.1000-0518.2016.12.160363
联合载体用于改善白藜芦醇固体分散体性能
Improve the Properties of Resveratrol Solid Dispersions by Combined Polymers
摘要
Abstract
Resveratrol ( Res ) binary and ternary solid dispersions solid dispersions with poly ( vinylpyrrolidone ) ( PVP ) and hydroxypropylmethylcellulose ( HPMC ) were prepared by the solvent evaporation.Solid dispersions were characterized by Fourier transform infrared spectroscopy ( FTIR), X-ray powder diffraction ( XRD) and modulated differential scanning calorimetry ( MDSC ) , and the release profiles were also invested .FTIR results reveal hydrogen bonding formed between Res and polymers .The release profiles of both Res solid dispersions are enhanced .However , XRD and MDSC results show that the miscibility of ternary solid dispersions is better than that of its binary solid dispersions .Under accelerated testing condition(40 ℃, 75%RH(relative humity)) for 3 months, XRD, MDSC and the release profiles indicate that Res ternary solid dispersions are more stable than that of its binary solid dispersions .The release profiles and stability of Res ternary solid dispersions are improved with the addition of HPMC .关键词
白藜芦醇/无定形固体分散体/氢键/溶出/稳定性Key words
resveratrol/amorphous solid dispersion/hydrogen bonding/dissolution/stability分类
化学化工引用本文复制引用
王冰,黄晓斌,赵姗,张建斌,吕岩,吕国军,马小军..联合载体用于改善白藜芦醇固体分散体性能[J].应用化学,2016,33(12):1383-1388,6.基金项目
国家自然科学基金资助项目（21576254）@@@@Supported by the National Natural Science Foundation of China （）
