原子能科学技术2016，Vol.50Issue(12)：2130-2137,8.DOI:10.7538/yzk.2016.50.12.2130
基于64Cu和超顺磁性氧化铁纳米粒子的PET／MRI双模态淋巴显像探针的研究
Investigation of PET/MRI Dual-modal Lymph Imaging Probe Based on 64 Cu and Superparamagnetic Iron Oxide Nanoparticle
孙钰林 1刘陆 2梁积新 1陈玉清 1沈浪涛1
作者信息
- 1. 中国原子能科学研究院国家同位素工程技术研究中心，北京 102413
- 2. 原子高科股份有限公司，北京 102413
- 折叠
摘要
Abstract
The dextran‐coated superparamagnetic iron oxide nanoparticles were synthe‐sized by the method of chemical co‐precipitation firstly ,then dithiocarbamate bisphos‐phonate (DTCBP) was labeled with 64Cu effectively ,and 64Cu(DTCBP)2 was obtained . By the binding properties of DTCBP to the iron oxide ,a PET/MRI dual‐modal lymph imaging probe of 64Cu(DTCBP)2‐IO‐Dex was prepared by mixing IO‐Dex and the pre‐labeling 64Cu(DTCBP)2 .The radiochemical purity of 64Cu(DTCBP)2‐IO‐Dex is higher than 99% after purification .The biodistribution of 64Cu(DTCBP)2‐IO‐Dex in Balb/C mice show s that the uptakes of popliteal lymph node and iliac lymph node are 2.31% ID and 1.84% ID at 1 h after injection ,respectively .At the same time ,the uptake of the liver is 15.41% ID/g .The radioactivity is no uptake in spleen until 3 h after injection . T he uptake of radioactivity in popliteal lymph node can be clearly observed in the mode of PET/CT or M RI .关键词
显像探针/PET/M RI/氧化铁纳米粒子/二磷酸盐/淋巴显像Key words
imaging probe/PET/M RI/iron oxide nanoparticle/bisphosphonate/lymph imaging分类
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孙钰林,刘陆,梁积新,陈玉清,沈浪涛..基于64Cu和超顺磁性氧化铁纳米粒子的PET／MRI双模态淋巴显像探针的研究[J].原子能科学技术,2016,50(12):2130-2137,8.
