中国比较医学杂志2016，Vol.26Issue(12)：27-31,5.DOI:10.3969/j.issn.1671-7856.2016.12.006
补肾促排卵汤对多囊卵巢综合征模型大鼠卵巢形态及性激素的影响
Effect of Bushencupailuan Decoction on ovarian morphology and sex hormone levels in rat models of polycystic ovary syndrome
摘要
Abstract
Objective To explore the effect of Bushencupailuan decoction , a Chinese medicine formula , on polycystic ovary syndrome ( PCOS ) and its mechanism through observing the sex hormones , anti-Müllerian hormone ( AMH) and the morphology of ovaries of PCOS rat models .Methods Bushencupailuan decoction was administered in DHEA-induced PCOS model rats .The pathology of ovaries was examined , and the serum sex hormones and AMH were detected.Results Compared with the normal group , the ovaries of model group rats had severe diffuse cystic dilatation and cystic cavities of different sizes .The granular layer cells were compressed into flat or cubical shapes .Corpora lutea and follicles in various stages of development were rare .Bushencupailuan decoction obviously improved the numbers of mature follicles and corpora lutea , levels of sex hormones and AMH of PCOS model rats compared with those of model rats ( P<0.05).Conclusions Bushencupailuan decoction can treat PCOS by improving the serum sex hormone levels in PCOS model rats, reduce serum AMH and help to restore ovulation .关键词
多囊卵巢综合征模型大鼠/补肾促排卵汤/性激素/抗苗勒氏管激素/卵巢形态Key words
Polycystic ovary syndrome , PCOS/Rat model/Bushencupailuan decoction/Sex hormones/Anti-Mullerian hormone , AMH/Morphology , ovary分类
医药卫生引用本文复制引用
郭银华,谈勇,邹奕洁..补肾促排卵汤对多囊卵巢综合征模型大鼠卵巢形态及性激素的影响[J].中国比较医学杂志,2016,26(12):27-31,5.基金项目
江苏省中医药局2010年度康缘中医药科技创新基金项目（HZ1010KY）。 （）
