中国畜牧兽医2016，Vol.43Issue(11)：2866-2872,7.DOI:10.16431/j.cnki.1671-7236.2016.11.009
可乐猪乳头数性状全基因组关联分析
Genome-wide Association Study of Teats Number Traits in Kele Pigs
摘要
Abstract
Teats number is one of the most important reproductive traits,and closely related to the economic benefit in pig industry.In order to reveal the underlying genetics of left teats number,right teats number and total teats number traits,a genome-wide association study (GWAS) was performed.Samples of DNA were collected to genotyping for 22 Kele pigs using the Illumina Porcine SNP 60K Chip.The GWAS was performed using a mixed-effects model and linear regression approach.When a genome-wide threshold was determined using the Bonferroni method (P<2.06E-5),4 single nucleotide polymorphism (SNP) markers were potentially associated with left teats number,right teats number and total teat number.However,3 SNPs were significant associated and 18 SNPs were potentially associated in chromosomes level.304 Ensembl genes were retrieved around 1 cM of the associated SNPs.The candidate genes in Wnt and Fgf signaling pathway (BTRC,FGF5,FGF8,BMP3,RASGEF1B and HMGB3) might have effect on target traits.These results provided valuable information about the selective breeding for Kele pigs.关键词
SNP芯片/全基因组关联分析/乳头数Key words
SNP chips/genome-wide association study/teats number分类
生物科学引用本文复制引用
谢健,喻昌燕,许瑶,牛熙,冉雪琴,王嘉福..可乐猪乳头数性状全基因组关联分析[J].中国畜牧兽医,2016,43(11):2866-2872,7.基金项目
国家高技术研究发展计划(863计划)课题(2013AA102503) （863计划）
贵州大学创新基金(2015009) （2015009）
贵州省农业攻关项目(黔科合NY[2013]3073号) （黔科合NY[2013]3073号）
贵州省科技创新人才团队建设专项(黔科合人才团队2009-4006) （黔科合人才团队2009-4006）
贵州大学"本科教学工程"项目(BKJX2012007) （BKJX2012007）
