中国畜牧兽医2016，Vol.43Issue(12)：3251-3256,6.DOI:10.16431/j.cnki.1671-7236.2016.12.025
蛹虫草多糖对注射环磷酰胺小鼠抗氧化功能的影响
The Effect of Cordyceps Militaris Polysaccharides on the Antioxidant Function in Mice Injected With Cyclophosphamide
摘要
Abstract
To investigate the antioxidant effects of the Cordyceps militaris polysaccharides (CMP),90 male BALB/c mice were randomly divided into six groups,three experimental groups (CMP groups),model control group (CY group),blank control group (BC group)and positive control group (PC group).The mice in CMP and CY groups were given cyclophosphamide at 80 mg/kg via intraperitoneal injection for 3 d.Then the CMP groups were administrated 17.5, 35.0 and 70.0 mg/(kg·BW)CMP via gavage,respectively,BC and CY groups were given phys-iological saline,and PC group was orally administered 70 mg/(kg·BW)CMP,lasting 18 d.At 24 h after the last administration,heart,liver and kidney were collected to measure the levels of MAD,CAT,SOD,GSH-Px and T-AOC in the homogenate.SOD and TAOC activity of three CMP groups increased significantly (P < 0.01 ),and the level of MDA decreased significantly (P <0.01)compared with CY group.As for CAT activity of heart,the value in low-dose CMP group had no significant change (P >0.05),while in middle and high-dose groups had significant (P <0.05 )and extremely significant(P < 0.01 )increase respectively.Except that the hepatic GSH-Px activity increased significantly (P <0.05 )in low-dose CMP group,the rest values of <br> GSH-Px activities in all CMP groups increased extremely significantly (P <0.01 ).The results indicated that CMP could effectively improve the antioxidant function of mice and had the potential to be a good resource of new antioxidant drugs.关键词
蛹虫草多糖/环磷酰胺/抗氧化活性/小鼠Key words
Cordyceps militaris polysaccharides/cyclophosphamide/antioxidant activity/mice分类
农业科技引用本文复制引用
王米,王宵旸,张丽芳,费陈忠,张可煜,王春梅,杨锐乐,薛飞群..蛹虫草多糖对注射环磷酰胺小鼠抗氧化功能的影响[J].中国畜牧兽医,2016,43(12):3251-3256,6.基金项目
公益性行业(农业)科研专项(201303040-08) （农业）
863计划课题“偶蹄动物用新型免疫佐剂的创新”(2011AA2114)。 （2011AA2114）
