中国卒中杂志2016，Vol.11Issue(12)：1030-1034,5.DOI:10.3969/j.issn.1673-5765.2016.12.007
基于磁共振动脉自旋标记技术指导的急性缺血性卒中静脉溶栓研究
Study on Magnetic Resonance Imaging-Arterial Spin Label-Guided Intravenous Thrombolysis in Acute Ischemic Stroke
摘要
Abstract
Objective To evaluate the effectiveness and safety of magnetic resonance imaging (MRI)-arterial spin label (ASL) guided intravenous thrombolysis in treatment of acute ischemic stroke (AIS), and to explore a new efifcient method of evaluating the intravenous thrombolysis of AIS. Methods Patients with AIS who were treated with recombinant tissue plasminogen activator (rt-PA) guided by MRI-ASL after 3 hours of symptom onset were enrolled as study group, and patients who were treated with rt-PA guided by MRI-perfusion-weighted imaging (PWI) were chosen as control group. The baseline information, medical history, image to needle time (INT), National Institutes of Health Stroke Scale (NIHSS) and modiifed Rankin's Score (mRS) within 90 d after treatment, the risk of hemorrhagic complications were assessed. Results There were neither signiifcant differences between two groups in the rate of hemorrhagic transformation, nor in the baseline. INT of ASL-group was significantly shorter than that of PWI-group [(65±15) minvs (73±11) min,P=0.031]. Conclusion Compared with MRI-PWI guided intravenous thrombolysis in treatment of AIS, MRI-ASL reduces time delay, and there was no signiifcant differences in the safety and effectiveness.关键词
急性缺血性卒中/静脉溶栓/动脉自旋标记技术/延误Key words
Acute ischemic stroke/Intravenous thrombolysis/Arterial spin labeling/Delay引用本文复制引用
许东,吕金捍,赵海燕,马东明,齐明山,王文虎,王巍,何文亭,姚翠萍,哈若水..基于磁共振动脉自旋标记技术指导的急性缺血性卒中静脉溶栓研究[J].中国卒中杂志,2016,11(12):1030-1034,5.基金项目
宁夏自然科学基金 （）
