磁共振成像2016，Vol.7Issue(12)：881-896,16.DOI:10.12015/issn.1674-8034.2016.12.001
2016年世界卫生组织中枢神经系统肿瘤分类概述
The 2016 World Health Organization classiifcation of tumors of the central nervous system：A summary
王凯 1张姝 2施露 2王鑫 2艾林 1戴建平3
作者信息
- 1. 首都医科大学附属北京天坛医院核医学科，北京 100050
- 2. 首都医科大学附属北京天坛医院放射科，北京 100050
- 3. 北京市神经外科研究所，北京 100050
- 折叠
摘要
Abstract
The 2016 World Health Organization classiifcation of tumors of the central nervous system is both a conceptual and practical advance over its 2007 predecessor. For the ifrst time, the WHO classiifcation of CNS tumors uses molecular parameters in addition to histology to deifne many tumor entities, thus formulating a concept for how CNS tumor diagnoses should be structured in the molecular era. As such, the 2016 CNS WHO presents major restructuring of the diffuse gliomas, medulloblastomas and other embryonal tumors, and incorporates new entities that are defined by both histology and molecular features, including glioblastoma, IDH-wildtype and glioblastoma, IDH-mutant; diffuse midline glioma, H3 K27M–mutant; RELA fusion–positive ependymoma; medulloblastoma, WNT-activated and medulloblastoma, SHH-activated;and embryonal tumor with multilayered rosettes, C19MC-altered. The 2016 edition has added newly recognized neoplasms, and has deleted some entities, variants and patterns that no longer have diagnostic and/or biological relevance. Other notable changes include the addition of brain invasion as a criterion for atypical meningioma and the introduction of a soft tissue-type grading system for the now combined entity of solitary ifbrous tumor/hemangiopericytoma-a departure from the manner by which other CNS tumors are graded. Overall, it is hoped that the 2016 CNS WHO will facilitate clinical, experimental and epidemiological studies that will lead to improvements in the lives of patients with brain tumors.关键词
中枢神经系统肿瘤/分类法/磁共振成像Key words
Central nervous system neoplasms/Classiifcation/Magnetic resonance imaging分类
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王凯,张姝,施露,王鑫,艾林,戴建平..2016年世界卫生组织中枢神经系统肿瘤分类概述[J].磁共振成像,2016,7(12):881-896,16.
