磁共振成像2016，Vol.7Issue(12)：897-901,5.DOI:10.12015/issn.1674-8034.2016.12.002
功能磁共振图像预处理全脑平均信号对静息态网络连接性的影响
The effect of global signal correction on the functional connectivity of resting brain networks
摘要
Abstract
Objective:To examine the effect of global signal correction on the functional connectivity in resting-state magnetic resonance imaging network analysis.Materials and Methods:Twenty-three healthy subjects underwent 5 minutes resting-state BOLD fMRI scanning. A method of time-series correlation analysis based on seed regions of posterior cingulate cortex (PCC) and left dorsal lateral prefrontal cortex (dLPFC) was employed to extract default mode network and executive control network. The resulting functional connectivity was compared between with and without global signal correction, while the other preprocessing conditions were identical.Results:The seeds correlation methods could extract default mode network and executive control network which coincided with previous studies, and could also acquire their negative correlated networks. Paired two-samplet test underP<0.005 statistic level with alphasim correction indicated that there were significant increased positive correlations at almost whole brain level.Conclusion:These results from this study show characteristic differences between the networks with and without global signal correction. The correlation coefifcients were positively biased in the methods without the whole brain signal correction, so more attention should be paid to the issue of global signal.关键词
脑/磁共振成像/功能连接/全脑平均信号/磁共振成像,功能Key words
Brain/Magnetic resonance imaging/Functional connectivity/Global signal/Magnetic resonance imaging, functional分类
医药卫生引用本文复制引用
张洪英,陈文新,田彤彤,叶靖,李洁,尹昳丽,吴晶涛..功能磁共振图像预处理全脑平均信号对静息态网络连接性的影响[J].磁共振成像,2016,7(12):897-901,5.基金项目
国家自然科学基金面上项目(编号81471624，81571652)ACKNOWLEDGMENTS This work was part of National Natural Science Foundation of China (No.81471624,81571652) （编号81471624，81571652）
