磁共振成像2016，Vol.7Issue(12)：921-925,5.DOI:10.12015/issn.1674-8034.2016.12.006
磁敏感加权成像技术鉴别乳头状和嫌色细胞肾癌的价值研究
Susceptibility weighted imaging in differentiating papillary from chromophobe renal cell carcinoma
摘要
Abstract
Objective:To differentiate papillary RCC (pRCC) from chromophobe RCC (CRCC) based on intratumoral susceptibility signals (ITSSs) detected on SWI.Materials and Methods:A retrospective review was performed on patients with CRCC (n=9) or pRCC (n=12) classiifed by pathology. The ITSSs were classiifed into hemorrhage and microvessels based on their morphology. NonparametricMann-Whitney test was used to compare the differences in the dominant structure of ITSSs, the number of intratumoral vessels and hemorrhagic lesions, and the ratio of ITSS area on SWI between pRCC and CRCC. The diagnostic values of the dominant structure of ITSSs, the number of intratumoral vessels and hemorrhagic lesions, and the ratio of ITSS area on SWI in differentiating pRCCs from CRCCs were compared by receiver operating characteristics (ROC).Results:ITSSs were seen in 18 of 21 patients. No ITSSs were seen in 3 patients with CRCC. Mean scores of dominant structures of ITSSs on SWI were significantly higher for pRCCs than that for CRCCs (P<0.005). There was signiifcant difference of the ratio of ITSS area on SWI between pRCCs and CRCCs (P<0.05). The number of hemorrhagic lesions in pRCCs was signiifcantly larger than that in CRCCs (P<0.05). The occurrence of intratumoral hemorrhage was more common in pRCCs (12/12, 100%) than that in CRCCs (6/9, 66.67%). The number of intratumoral hemorrhagic lesions revealed the highest positive predictive value (100%) and speciifcity (100%) as compared with other features, while the ratio of ITSS area on SWI showed the highest positive predictive value (87.5%) and sensitivity (88.89%).Conclusion:SWI is a useful technique to analyze the structural difference between pRCC and CRCC by the dominant structures ITSSs, the number of intratumoral hemorrhagic lesions, as well as the ratio of ITSS area on SWI.关键词
磁共振成像/磁敏感加权成像/肾肿瘤/癌,肾细胞/亚型Key words
Magnetic resonance imaging/Susceptibility weighted imaging/Kidney neoplasms/Carcinoma, renal cell/Subtype分类
医药卫生引用本文复制引用
张永成,俞胜男,陈杰,孙军,邢士军,陈铜兵..磁敏感加权成像技术鉴别乳头状和嫌色细胞肾癌的价值研究[J].磁共振成像,2016,7(12):921-925,5.基金项目
国家自然科学基金面上项目(编号81371513)ACKNOWLEDGMENTS This work was part of National Natural Science Foundation of China (No.81371513) （编号81371513）
