重庆医学2016，Vol.45Issue(36)：5088-5090,5094,4.DOI:10.3969/j.issn.1671-8348.2016.36.015
IMRT联合HIFU治疗手术及TACE术后复发原发性肝癌的临床研究
Clinical research of IMRT combined with HIFU for inoperatable recurrent primary hepatic carcinoma after operation and TACE
摘要
Abstract
Objective Toexploretheclinicalefficacyandtoxicityofintensitymodulatedradiationtherapy(IMRT)combined with high intensity focused ultrasound(HIFU) for inoperatable recurrent hepatic carcinoma after operation and TACE .Methods Total 60 patients with inoperatable recurrent hepatic carcinoma after operation and TACE were randomly divided into two group ,30 patients in observation group received IMRT and HIFU ,while 30 patients in control group received only IMRT .For both groups , the same radiotherapy technic was given with IMRT in 6 MV X‐ray ,the total dose was 54 -70 Gy/6 -7 weeks .In observation group ,HIFU was carried out concurrently with IMRT (5 days/week ,6-7 weeks) .Results The difference of the short‐term effi‐cacy between the observation group and the control group was statistically significant (P<0 .05) ,there was no significant difference in acute radioactive toxicity between the two groups (P>0 .05) .The one and two year overall survival rate 89 .9% ,78 .9% in obser‐vation group ,while 72 .8% ,36 .2% in control group ,the differnces were statistically significant (P<0 .05);the one and two year progression‐free survival rate were 85 .9% and 50 .9% in observation group ,while 64 .3% and 28 .1% in control group ,the differ‐ences between two groups were statistically significant (P<0 .05) .The medium survival time was 36 months in observation group , and 24 months in control group;the medium progression‐free survival was 27 months in observation group ,and 17 months in control group .Conclusion For recurrent unresectable or reject surgery after TACE in patients with primary hepatic carcinoma ,the efficacy of IMRT combined with HIFU treatment is effective ,the toxicity can be tolerated ,and has certain application value .关键词
原发性肝癌/放射疗法,调强适形/高强度聚焦超声Key words
hepatic carcinoma/radiaotherapy ,intensity-modulated/high intensity focused ultrasound分类
医药卫生引用本文复制引用
许涛,景红霞,李林均,张军,余建云,程雄飞,焦娇..IMRT联合HIFU治疗手术及TACE术后复发原发性肝癌的临床研究[J].重庆医学,2016,45(36):5088-5090,5094,4.基金项目
十堰市科学技术研究与开发项目（16Y46）；十堰市人民医院青年英才项目（14-7）。 （）
