动物医学进展2016，Vol.37Issue(12)：82-85,4.
C型产气荚膜梭菌致病机理研究进展
Progress on Pathogenesis Mechanism of Clostridium perfringens Type C
摘要
Abstract
Clostridium perfringens type C causes necrotizing enteritis in humans and some animal species. Type C isolates produce beta toxin (CPB)and alpha toxin (CPA)and most strains produce several other toxins including perfringolysin O (PFO)and TpeL.However,current evidence indicates that CPB is the main virulence factor for type C infections.The rabbit intestinal loop and mouse model experiments showed that C.perfringens type C toxin βgene knockout mutant strain caused the loss of virulence,and the virulence was regained when these mutants were complemented with the wild-type cpb gene.Many type C isolates respond to contact with enterocyte-like Caco-2 cells by producing all toxins,except TpeL, VirS/VirR two-component regulation system (TCRS)proved rapid Caco-2 cell-induced upregulation of CPB and PFO production.The upregulated in vivo transcription of the pfoA and cpb genes was blocked by inactivating the VirR gene,and was reversible by restoring VirR expression.The animal mode experimen-tal research of beta toxin may find effective precautionary measures.关键词
C型产气荚膜梭菌/β毒素/致病机制/坏死性肠炎Key words
Clostridium perfringens type C/beta toxin/pathogenesis/necrotizing enteritis分类
农业科技引用本文复制引用
李凡飞,张云,李强,赵泽慧,何小丽,许立华..C型产气荚膜梭菌致病机理研究进展[J].动物医学进展,2016,37(12):82-85,4.基金项目
宁夏“优质高产奶牛遗传改良与选育”专项 （）
