工业微生物2016，Vol.46Issue(6)：54-58,5.DOI:10.3969/j.issn.1001-6678.2016.06.009
酿酒酵母合成异源单萜类化合物的研究进展
Research advances of heterologous synthesis of monoterpenes in Saccharomyces cerevisiae
摘要
Abstract
Monoterpenes are widely used in food, medicine and industries, which have great economical values. With the development of synthetic biology, monoterpenes synthesis using microbial cell as factory have become a hot research topic. Saccharomyces cerevisiae is a model eukaryotic expression strain, mevalonate pathway provides precursors for the synthesis of monoterpenes, so it has great advantages to construct heterologous monoterpenes synthesis pathway. The construction of heterologous monoterpenes synthesis pathway in Saccharomyces cerevisiae was introduced. The research advances in heterologous expression of monoterpenes in Saccharomyces cerevisiae were reviewed from regulatory mechanisms of metabolic flux of mevalonate pathway and regulation of enzyme catalytic efficiency using fusion enzymes.关键词
酿酒酵母/甲羟戊酸途径/单萜类化合物/代谢/融合酶Key words
Saccharomyces cerevisiae/mevalonate pathway/monoterpenes/metabolism/fusion enzymes引用本文复制引用
孙明雪,周景文..酿酒酵母合成异源单萜类化合物的研究进展[J].工业微生物,2016,46(6):54-58,5.基金项目
国家自然科学基金重点项目(31130043),国家自然科学基金(31000807),江苏省自然科学基金重点项目(BK2011004),江苏省自然科学基金(BK2010150). （31130043）
