湖南中医药大学学报2016，Vol.36Issue(12)：7-10,4.DOI:10.3969/j.issn.1674-070X.2016.12.002
凉膈散、银翘散对早期脓毒症炎症因子干预作用比较研究
Comparisons of the Effects of Liangge Powder and Yinqiao Powder on Inflammatory Cytokines in Early Stage of Sepsis
摘要
Abstract
Objective To observe different effects of Liangge Powder and Yinqiao Powder on inflammatory cytokines IL-1β, TNF -α and IL -10 in early stage of sepsis. Methods 40 rabbits were randomly divided into blank con-trol group, model group, Yinqiao Powder therapy group, Liangge Powder therapy group and dexamethasone control group. The sepsis model was established by injecting LPS into rabbits' ear vein, which was given drug intervention after 0.5 h of modeling. After 4 h of modeling, the general conditions, temperatures, levels of plasma endotoxin, IL-1β, TNF-α and IL-10 were observed. Results Symtoms in Yinqiao Powder therapy groups were relieved, and their temperatures, levels of plasma endotoxin, IL-1β and TNF-α decreased compared with model group (P<0.01 or P<0.05). Symptoms in Liangge Powder thera-py group turned into more serious, levels of plasma endotoxin, IL-1β, TNF-α and IL-10 had no significant difference com-pared to model group (P>0.05). Conclusion Yinqiao Powder can inhibit the releases of pro-inflammatory cytokines of IL-1βand TNF-α in Weifen syndrome related phase of early stage of sepsis, and it can reduce the inflammatory reaction and re-lieve the symptoms, while Liangge Powder can not.关键词
银翘散/凉膈散/脓毒症/卫分证/炎症因子Key words
Yinqiao Powder/Liangge Powder/sepsis/Weifen syndrome/inflammatory cytokines分类
医药卫生引用本文复制引用
何宜荣,赵国荣,肖碧跃,何栋,贺又舜,艾碧琛..凉膈散、银翘散对早期脓毒症炎症因子干预作用比较研究[J].湖南中医药大学学报,2016,36(12):7-10,4.基金项目
国家自然科学基金项目（30801473，81603535），湖南省自然科学基金项目（14JJ3119），湖南中医药大学“中医经典理论与经方应用研究”科技创新团队项目，湖南中医药大学中医临床基础重点学科。 （）
