湖南中医药大学学报2016，Vol.36Issue(12)：17-20,4.DOI:10.3969/j.issn.1674-070X.2016.12.004
柴胡三参胶囊对缺血性心律失常大鼠心肌细胞Cx43的影响
Effect of Chaihu Sanshen Capsule on Cx43 in Myocardial Cells of Rats with Ischemic Arrhythmias
摘要
Abstract
Objective To investigate the effect of Chaihu Sanshen capsule on the expression and distribution of connex-in 43 (Cx43) of gap junction in myocardial cells of rats with ischemic arrhythmias, and provide experimental basis for clinical application of Chaihu Sanshen capsule. Methods The rats were randomly divided into blank group, sham opera-tion group, model group, Chaihu Sanshen capsule (Qinghao group), Chaihu Sanshen capsule (Changshan group), amio-darone group and Wenxin granules group, 10 rats in each group. After intervention for 10 d, in addition to the blank group and the control group, the other rats were made myocardial ischemic arrhythmias model of left anterior descending coronary artery ligation. The expression and distribution of Cx43 protein miocadial cells of rats was detected by immunohistochemical S-P method. Results The Cx43 gray scale of Chaihu Sanshen capsule (Qinghao group) and Chiahu Sanshen capsule (Chang-shan group) had no significant difference (P>0.05). The arrhythmia score of Chaihu Sanshen capsule was lower (P<0.05) and a decrease in mortality, CX43 average gray value increased (P<0.05) and distribution disorder to improve. Conclusion Chaihu Sanahen capsule (Qinghao) and Chaihu Sanahen capsule (Changshan) both can improve the expression and distribution of Cx43 in myocardial ischemia cell, protect cardiac muscle and to reduce the incidence of ischemic arrhythmias, and Chaihu Sanshen capsule (Qinghao) shows higher clinical safety.关键词
柴胡三参胶囊/缺血性心律失常/缝隙连接蛋白43/常山/青蒿Key words
Chaihu Sanshen capsule/ischemic arrhythmias/Connexin 43/Changshan/Qinghao分类
医药卫生引用本文复制引用
刘建和,王建国,尹萍,杨成龙,唐银,周正,刘锦霞..柴胡三参胶囊对缺血性心律失常大鼠心肌细胞Cx43的影响[J].湖南中医药大学学报,2016,36(12):17-20,4.基金项目
湖南省科技厅科研项目（2013SK3103）；湖南省中医药管理局重点课题（201303）；湖南省重点实验室开放基金计划项目（2014XN-FZ03）；湖南省科技创新项目投资计划（[2014]658）；2015年湖南省学位与研究生教育教改研究课题（JG2015B071）。 （）
