湖南中医药大学学报2016，Vol.36Issue(12)：85-90,6.DOI:10.3969/j.issn.1674-070X.2016.12.021
加兰他敏合成途径的研究进展
Advances in the Synthesis Pathways of Galanthamine
摘要
Abstract
Galanthamine is a drug that is widely used in the treatment of Alzheimer's disease and etc. But according to the studies, the extraction yield of galanthamine in natural plants is very limited, researchers have studied on the synthesis of galanthamine. So far, a variety of chemical synthesis strategies were proposed. However, due to the defects of the current chemical synthesis, such as low yield, high cost, complicated steps and etc, the methods are not conducive to practical production, at present, the most effective alternative is to explore the biosynthetic methods for galanthamine. The review summarizes the research advances in the synthesis of galantamine, and emphatically introduces the biosynthesis and synthesis-related enzymes of galantamine, the further study prospects of galantamine's synthesis are expected.关键词
加兰他敏/生物合成途径/关键酶/基因调控/石蒜Key words
galanthamine/biosynthetic pathway/key enzyme/gene control/Lycoris radiata (L'Her.) Herb分类
医药卫生引用本文复制引用
周日宝,刘畅宇,彭美晨,王朝晖,刘湘丹..加兰他敏合成途径的研究进展[J].湖南中医药大学学报,2016,36(12):85-90,6.基金项目
湖南省科技厅（2015SK2015）；国家中医药管理局“药用植物学”重点学科资助（国中医药发[2009]30号）；湖南省科技厅（2015NK2153）；湖南省“中药学”重点学科建设项目资助（湘教通[2011]76号）；湖湘中药资源保护与利用协同创新中心（湘教通[2015]351号）。 （）
