临床神经病学杂志2016，Vol.29Issue(6)：401-404,4.
急性缺血性卒中后抑郁的相关危险因素分析
Analysis of relevant risk factors of acute ischemic post-stroke depression
摘要
Abstract
Objective To study the incidence rate of acute ischemic post-stroke depression ( PSD ) and its relevant risk factors .Methods One hundred and eighty-five acute ischemic stroke patients confirmed with CT or MRI were divided into PSD group and non-PSD group by the Diagnostic and Statistical Manual of Mental Disorder-V ( DSM-V) criteria and 24-item Hamilton Depression Rating Scale ( HAMD) .The influence factors on PSD including social demographic data , vascular risk factors , relevant biochemical indicators , NIHSS, Barthel Index ( BI ) and MMSE were analyzed.Results In this group , the incidence of PSD was 40.54%(75 cases), was mainly composed of mild and moderate depression .Compared with non-PSD group, PSD group had a higher diabetes incidence rate (P=0.044), more severe neural function deficiency and worse activities of daily living (P=0.000, P=0.001), and lower MMSE scores(P=0.000), while high-sensitivity C-reaction protein (hs-CRP) and homocysteine (Hcy) levels increased (P=0.000, P=0.006).BI and MMSE scores were negatively correlated with HAMD scores (all P<0.05), while NIHSS scores, hs-CRP and Hcy levels were positively correlated with HAMD scores ( all P<0.05).The Logistic regression analysis indicated that , low MMSE scores, high NIHSS scores, high hs-CRP and Hcy levels might be independent risk factors of acute ischemic PSD .Conclusions PSD is mainly composed of mild and moderate depression .PSD is closely related with diabetes history , cognition impairment , neural function deficiency degree, hs-CRP and Hcy levels.关键词
缺血性脑卒中/卒中后抑郁/超敏C-反应蛋白/同型半胱氨酸Key words
ischemic stroke/post-stroke depression/high-sensitivity C-reactive protein/homocysteine分类
医药卫生引用本文复制引用
杨彩梅,李雪斌,王洁,黄建敏,蒙兰青,李保生,陆皓,吴为民..急性缺血性卒中后抑郁的相关危险因素分析[J].临床神经病学杂志,2016,29(6):401-404,4.基金项目
国家自然科学基金 （）
