泸州医学院学报2016，Vol.39Issue(6)：516-519,4.DOI:10.3969/j.issn.1000-2669.2016.06.006
卵圆孔单向活瓣术对室缺伴重度肺高压患者术后早期ET-1表达影响的研究
Effect of foramen ovale unidrectional valved pacth on the expression of ET-1 at the early stage post-surgery in VSD patients with severe PAH
摘要
Abstract
Objective: To evaluate the effect of foramen ovale unidrectional valved pacth on the expression of ET-1 at the early stage post-surgery in VSD patients with severe PAH. Methods:Eighteen cases of VSD patients with the severe PAH assessed by echocardiography were divided into two groups, unidrectional valved pacth group(n = 11) and the conventional surgery group (n = 7). All cases were repaired under cardiopulmonary bypass. Serum ET-1 of all cases were analyzed prior to operation and at 2 h, 4 h, 8 h, 16 h, 24 h, and 3 d post-operation using enzyme immunoassay. Data were analysed using SPSS17.0 software, and P < 0.05 was considered statistically significant. Results: There were no significant differences between the two groups in terms of demographic information. There were significant differences of the levels of plasma ET-1 between pre-operation and postoperation at 2 h, 4 h, 8 h, 16 h, 24 h, and 3 d in the Unidrectional Valved Pacth group, and between pre-operation and postoperation at 24 h and 3 d in the conventional surgery group. There were no significant differences of the plasma ET-1 between the two groups. One patient was dead after operation in each group. Conclusion: Postoperative plasma ET-1 expression was markedly reduced in the unidrectional valved pacth group, and the reduction happened earlier than the conventional surgery group, indicating unidrectional valved pacth maybe good to reduce the occurrence of PAH crisis at the early stage post-operation.关键词
单向活瓣/室间隔缺损/肺动脉高压/ET-1Key words
Unidrectional valved pacth/Ventricular septal defect/Pulmonary artery hypertension/ET-1分类
临床医学引用本文复制引用
邓明彬,付勇,廖斌,于风旭,方易冰..卵圆孔单向活瓣术对室缺伴重度肺高压患者术后早期ET-1表达影响的研究[J].泸州医学院学报,2016,39(6):516-519,4.基金项目
泸州市科技局基金资助项目（编号：2011-S-16（4/4）） （）
