泸州医学院学报2016，Vol.39Issue(6)：542-546,5.DOI:10.3969/j.issn.1000-2669.2016.06.013
乳腺浸润性微乳头状癌临床病理学特征分析
Clinical and pathological features of IMPC
摘要
Abstract
Objective: This article describes the pathological features of IMPC using immunohistochemical staining of a panel of proteins, as well as the discussion of the prognosis of IMPC in combination with the literature review. Methods: Twenty three IMPC cases (IMPC group) confirmed during Feb. 2011 to Sep. 2015 from our hospital and 71 invasive ductal carcinoma (IDC) cases (IDC group) were compared to analyze the pathological features between the two groups. Results: Microscopically, IMPC shows clusters of tumor cells in a micro-papillary or pseudoglandular form. Varying lacuna can be found between the tumor cell clusters and the surrounding mesenchyme. The comparison in terms of the age, maximum diameter of tumor, WHO grading and nuclear grade between the two groups present no statistical difference (P> 0.05). Rate of lymph node metastasis is significantly higher in IMPC(91.3%)than in IDC(62%)(P<0.05). Positive rates of various proteins for IMPC group and IDC group are: 91.3% VS 66.2% for ER, 69.6% VS 60.6% for PR, 17.4% VS 23.9% for HER-2, 69.6% VS 74.6% for Ki67, and 52.2% VS 64.8% for P53. Of all positive proteins, the positive rate of ER in IMPC group was obviously higher than that in IDC group (P < 0.05), whereas no statistical significance was observed in other proteins studied above (P>0.05). Conclusion:As a rare special type of invasive cancer, IMPC patients are easier to get lymph nodes metastasis as compared with IDC patients. A combined evaluation is warranted since high expression of ER alone doesn't necessarily mean good prognosis.关键词
浸润性微乳头状癌/浸润性导管癌/临床病理学/免疫组织化学/预后Key words
Invasive micropapillary carcinoma/Invasive ductal carcinoma/Clinical pathology/Immunoh-istochemistry/Prognosis分类
医药卫生引用本文复制引用
吴霜,叶入裴,肖秀丽,黄廷玉..乳腺浸润性微乳头状癌临床病理学特征分析[J].泸州医学院学报,2016,39(6):542-546,5.基金项目
泸州市科技局计划项目 （）
