中南医学科学杂志2016，Vol.44Issue(6)：617-619,624,4.DOI:10.15972/j.cnki.43-1509/r.2016.06.003
干扰素联合拉米夫定治疗e抗原阳性的HBV患者临床疗效分析
Analysis of Clinical Effect of Interferon and Lamivudine on the Patients with e Positive HBV
滕丹华 1张劲 1龚天斌 1程莉 1张天1
作者信息
- 1. 湖北省应城市人民医院，湖北 应城432400
- 折叠
摘要
Abstract
Objective To analyse the clinical effect of interferon and lamivudine on the patients with e positive HBV. Methods Clinical data of 105 patients with e antigen positive HBV in our hospital from Jul 2012 to Jul 2014 were retrospectively analyzed.The patients treated with lamivudine served as the control group (n=52),and the patients treated with pegylated interferon and lamivudine served as research group (n=53).All patients were treated for 12 months.The cur-ative effect was observed,HBV DNA,HBV antigen seroconversion rate,the level of alanine aminotransferase ( ALT) and the adverse reaction incidence were compared. Results Compared with the total effective rate 82.69% of control group,the research group had a higher total effective rate (92.45%,P<0.05).The negative transfer rate of HBeAb/HBeAg,HBsAg, HBV DNA,were significantly higher in the research group (P<0.05).Compared with the control group,the ALT level was lower after treatment for 3 months,12 months (P<0.05).The adverse reaction in duration of treatment in the two groups is not different. Conclusion HBV e antigen positive patients treated with interferon combined with lamivudine therapy can improve the serum ALT,HBV DNA level,HBeAb/HBeAg conversion rate,HBsAg and HBV DNA negative conversion rate, with less adverse reaction,which is safe,effective,and worthy of being popularized.关键词
e抗原阳性/HBV/干扰素/拉米夫定Key words
e antigen positive/HBV/interferon/lamivudine分类
医药卫生引用本文复制引用
滕丹华,张劲,龚天斌,程莉,张天..干扰素联合拉米夫定治疗e抗原阳性的HBV患者临床疗效分析[J].中南医学科学杂志,2016,44(6):617-619,624,4.
