中南医学科学杂志2016，Vol.44Issue(6)：664-666,718,4.DOI:10.15972/j.cnki.43-1509/r.2016.06.016
宫颈癌组织中COX2、P 21、MMP-9的蛋白表达及临床意义
Implication and Expression of COX2,P21 and MMP-9 in Cervical Cancer Tissues
侯宇1
作者信息
- 1. 四川省广元市中心医院，四川 广元628000
- 折叠
摘要
Abstract
Objective To investigate the expression of cyclooxygenase-2 ( COX-22) ,P21 and matrix metalloprotein-ase-9 ( MMP-9) in cervical cancer tissues and analyse its significance. Methods The clinical data of 48 patients with confirmed cervical cancer who underwent surgery ( Study group) were analyzed retrospectively. 50 patients who underwent hysterectomy because of other reasons were served as control group.The expression of COX2,P21 and MMP-9 in cervical tissues was tested by immuno histochemistry in the two groups. Results The positive rates of MMP-9 and COX-2 in cer-vical tissues in the study group were significantly higher than those in control group ( P<0.05) ,and those in patients at clin-ical stage Ⅰ~Ⅱ were significantly lower than those at stageⅢ~Ⅳ(P<0.05).P21 positively expressed in cervical tissues of patients with adenocarcinoma in study group and control group,and the positive rate was 0.0% while the negative rate and positive rate in patients with squamous cell carcinoma in study group ( 30. 6% and 69. 4%) were significantly higher than those in patients with adenocarcinoma in the same group and patients in the control group ( P<0.05) . Conclusion COX-2,MMP-9 and P21 are highly expressed in cervical cancer tissues,and the expression levels of COX-2 and MMP-9 are closely related to clinical stage while the expression level of P21 is closely related to the pathological type.关键词
宫颈癌/环氧化酶-2/P21/基质金属蛋白酶-9Key words
cervical cancer/COX2/P21/MMP-9分类
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侯宇..宫颈癌组织中COX2、P 21、MMP-9的蛋白表达及临床意义[J].中南医学科学杂志,2016,44(6):664-666,718,4.
