Abstract
Objective:To study the syndrome types of traditional Chinese medicine(TCM) in diabetic nephro-pathy(DN),and to explore the correlation between syndrome types of TCM and renal function,urinary protein, blood glucose and blood lipid. Methods:Based on clinical stages,335 DN patients were divided into four groups in this research:136 patients in the preclinical stage,102 patients in the early clinical stage,55 pa-tients in the clinical stage,and 42 patients in the end stage. Statistical analyses were performed according to the stage division,root disease and branch disease. During the research 24-hr urinary protein,blood urea ni trogen (BUN),serum creatinine (SCr),glycosylated hemoglobin (HbA1c),total cholesterol (TC),triglyceride (TG), low density lipoprotein(LDL-C) of those patients were measured. Results:In the preclinical stage group,there were 92 cases of deficiency of both qi and yin,accounting for 67.65%,and 44 cases of yin deficiency and dry heat,accounting for 32.35%,but no case of deficiency of both yin and yang. In the early clinical stage group,there were 89 cases of deficiency of both qi and yin,accounting for 87.25%,and 13 cases of yin de-ficiency and dry heat,accounting for 12.75%. In both clinical stage group and end stage group,cases of de-ficiency of both yin and yang were predominant,accounting for 63.64% and 80.95%,respectively. No signifi-cant difference was found in urinary protein,BUN and SCr of patients with yin deficiency and dry heat and deficiency of both qi and yin,and the difference were not statistical significant(P>0.05). Compared with pa-tients of yin deficiency and dry heat and patients with deficiency of both qi and yin ,patients of deficiency of both yin and yang showed increased levels of urinary protein,BUN,SCr,TC,TG,LDL-C,and the difference were statistical significant (P<0.01),but levels of HbA1c were irrelevant to syndrome types of TCM. Compared with patients of blood stasis,patients of phlegm dampness and fluid dampness showed in-creased levels of urinary protein,BUN,SCr,TC,TG, LDL-C,and the difference were statistical significant(P<0.05 or P<0.01). The level of SCr in patients with fluid dampness was significantly higher than the those with phlegm and dampness syndrome ,and the differ-ence were statistical significant(P<0.01). Conclusion:The development of DN is from yin deficiency and dry heat to deficiency of both qi and yin,and finally deficiency of both yin and yang. Levels of urinary protein, BUN,SCr,TC,TG,LDL-C in DN patients showed correlation with syndrome types of TCM.关键词
糖尿病肾病/中医证型/生化指标/相关性研究Key words
diabetic nephritis/syndrome types of traditional Chinese medicine,biochemical indices,study on the correlation分类
医药卫生
