世界中医药2016，Vol.11Issue(11)：2216-2218,2222,4.DOI:10.3969/j.issn.1673-7202.2016.11.003
肾虚血瘀证树鼩动物模型构建初探
Study on Tree Shrews Model of Kidney Deficiency and Blood Stasis
摘要
Abstract
Objective:To explore the way to establish the kidney and blood stasis model in tree shrew .Methods: Tree shrews were randomly divided into 3 groups:normal group , model group 1 ( injection of Hydrocortisone and Adrenaline ) and model group 2 ( injection of Hydrocortisone and Carrageenan ) .The kidney deficiency and blood stasis model was evaluated by observation of representation of tree shrews , detecting visceral index , hemorheology parameters and the level of hypothalamus-pituitary-target gland axis ( thyroid axis , gonad axis ) .Results: The animal been treated all appeared “exhausted” phenomenon , the kidney , prostate, spleen, testis of the model groups were swelling , but the thyroid in model group 2 was atrophied.The levels of E2 and T in model group 1, levels of FT3、FT4 and E2 in model group 2 declined remarkably .The results of hemorheology showed that the blood viscosity and hematocrit increased in model group 1.Conclusion: The tree shrews model of kidney deficiency and blood stagnation can be established by injection of hydrocortisone and adrenaline .关键词
肾虚血瘀/树鼩/动物模型Key words
Kidney deficiency and blood stasis/Tree shrew/Model分类
医药卫生引用本文复制引用
郭尔楚,黄金兰,陈奔,郭茜茜,冯晓桃,钟振国..肾虚血瘀证树鼩动物模型构建初探[J].世界中医药,2016,11(11):2216-2218,2222,4.基金项目
广西科学研究与技术开发计划项目 （）
