摘要
Abstract
Objective:To evaluate the efficacy of Chinese medicine ( CM) on TGF-β1 and ET of Chronic Obstructive Pulmonary Disease(COPD) systematically.Methods:Six electronic databases, either Chinese or English, were searched for randomized con-trolled trials ( RCTs) published until April 2016.RevMan 5.3 was used to analysis the data of the included RCTs .Results:Com-pared with a conventional therapy used alone , treatment with CM as an additional intervention was more effective on TGF-β1 (mean difference (MD)=-29.69, 95% confidence interval (CI) =( -44.16,-15.21),P<0.00001, I2=98%, random effects model, 260 cases, 4 studies) and so as to that of ET [MD=-7.7, 95%CI=( -10.97,-4.43),P<0.00001, I2=80%, random effects model, 304 cases, 5 studies].Both of the difference were statistically significant .Conclusion:CM improved TGF-β1 and ET of COPD .Considering the inherent limitations of the included studies , multicenter and larger high-quality RCTs should be performed to validate these findings in the future .关键词
中药/慢性阻塞性肺病/TGF-β1/ET/系统综述Key words
Chinese herbal medicine/Chronic Obstructive Pulmonary Disease/TGF-β1/ET/Systematic review分类
医药卫生
