摘要
Abstract
Objective:To evaluate the expression of HtrA4 and Syncytin-1 in maternal plasma and placental tissues,detect the value of S/D,PI,RI in umbilical artery blood flow. To explore the correlation between HtrA4 and Syncytin-1 expression with the pathogenesis of pre-eclampsia. Methods:Severe preeclampsia and normal pregnant women who were admitted to the Department of Obstetrics and Gynecology,the Second Hospital of Hebei Medical University dur-ing Feb. 2014 and May 2015. A total of 107 pregnant women were enrolled in the study,with 39 in early onset preeclampsia ( E-PE) ,35 in late onset severe preeclampsia ( LS-PE) and 33 in the control group. All women delivered by cesarean section ( CS) were included as cases. S/D, PI and RI were measured by using color doppler ultrasonic. Enzyme-linked immunosorbent as-say( ELISA) was used to measure the concentration of HtrA4 and Syncytin-1 in blood. The dis-tribution of HtrA4,Syncytin-1 in the placenta was observed by Immunohistochemical techniques ( IHC) and mean optical density value( MOD) . Results:The concentration of HtrA4 in the ma-ternal plasma and placenta tissue was significantly higher in E-PE compared with LS-PE and normotensive pregnancy respectively(P<0. 01,respectively). On the contrary,the concentration of Syncytin-1 in the maternal plasma and placenta tissue was decreased significantly in E-PE compared to LS-PE and normotensive pregnancy respectively(P<0. 01,respectively). Compared with the control group,the value of S/D in E-PE was significantly higher than the normotensive pregnancy and LS-PE(P<0. 05,respectively). The value of PI,RI were significantly higher than the normotensive pregnancy and LS-PE (P<0. 05,respectively),and as the same with the value of PI, RI in LS-PE was also significantly higher compared with the control group ( P<0. 05). Conclusions:HtrA4 and Syncytin-1 may involved in the pathogenesis of PE,and corre-lated with severity of PE. There is a negative correlation between the level of HtrA4 and the birth weight of newborns both in maternal plasma and placenta tissue in preeclampsia,and posi-tive correlation between HtrA4 levels and S/D、PI、RI. Whatever a negative correlation between the level of Syncytin-1 and the birth weight of newborns,negative correlation between Syncytin-1 levels and S/D,PI,RI.关键词
子痫前期/HtrA4/Syncytin-1/S/D/胎盘浅着床Key words
Preeclampsia/HtrA4/Syncytin-1/S/D/Shallow placental implantation分类
医药卫生
