现代妇产科进展2017，Vol.26Issue(1)：15-18,22,5.DOI:10.13283/j.cnki.xdfckjz.2017.01.003
妊娠期高血压疾病AGEs、RAGE、TGF-β1的表达
Expression of AGEs、RAGE、TGF-β1 in hypertensive disorders complicating pregnancy
摘要
Abstract
Objective:To investigate the relationship between expression of advanced glycation end product (AGEs),its receptor RAGE,transforming growth factor-β1(TGF-β1) and hypertensive disorders complicating pregnancy. Methods:Samples from 900 pregnant women who presented to the Affiliated Hospital of Nangtong University for prenatal care from Aug. 2014 to Oct. 2015 were included in this prospective study,of which 15 were subsequently developed hypertensive disorders complicating pregnancy as case group ( preeclampsia 6 and gestational hypertension 9) and 15 were normal pregnant women as control. The matemal serum was conducted in their second(between 16 th to 20th week of pregnancy) and third (between 34th to 36th week of pregnancy) trimester of pregnancy. Expression of serum AGEs,RAGE, TGF-β1 were detected by Elisa. Expression of AGEs,RAGE,TGF-β1 in the placentas were de-tected by immunohistochemical staining. Result:In the second trimester of pregnancy,the ex-pression levels of AGEs,RAGE,TGF-β1 in the peripheral blood of pregnant women with pre-eclampsia were significantly higher than those in the control group ( P<0 . 05 ) . The expression level of TGF-β1 in gestational hypertension was significantly higher than that in the control group (P<0. 05). In the third trimester of pregnancy,the expression levels of AGEs and TGF-β1 in the peripheral blood of pregnant women with preeclampsia and gestational hypertension were both significantly higher than those in the control group (P<0. 05),while the expression level of Rage in preeclampsia was significantly higher than those in gestational hypertension and the normal control group. (P<0. 05). Positive expressions of AGEs,RAGE,TGF-β1 were de-tected in the placenta of preeclampsia. Positive correlations were observed among AGEs,RAGE,TGF-β1. Conclusions:Expression of AGEs, RAGE, TGF-β1 are associated with pre-eclampsia.关键词
晚期糖基化终末产物/转化生长因子-β1/子痫前期Key words
Advanced glycation end product/Transforming growth factor-β1/Rage/Preeclampsia分类
医药卫生引用本文复制引用
苏敏,张玉泉,姚微,叶霖,施建,黄华,苏丽,邱亚萍..妊娠期高血压疾病AGEs、RAGE、TGF-β1的表达[J].现代妇产科进展,2017,26(1):15-18,22,5.基金项目
南通大学附属医院转化医学基地科研项目(No:TDFzh2014) （No:TDFzh2014）
