中国组织工程研究2016，Vol.20Issue(51)：7738-7745,8.DOI:10.3969/j.issn.2095-4344.2016.51.021
外泌体中Micro-RNA可作为疾病的生物标志物？
Can exosomal micro-RNAs be as biomarkers of diseases?
摘要
Abstract
BACKGROUND:Exosome, a kind of cystic vesicle with bilayer structure, is widely distributed in the body fluids. Exosomes are involved in various cel ular communications, and its contents including proteins, short chain peptides, DNA, RNA, phospholipids, and miRNA are resistant to degradation. <br> OBJECTIVE:To clarify the characters of exosomes, and to investigate the possibility of exosomal miRNAs as biomarkers for different diseases to provide a new strategy for clinical diagnosis. <br> METHODS:A computer-based search of CNKI and PubMed databases was performed by the first author for articles related to exosomal miRNAs. The keywords were“exosome, microvesicles, extracel ular vesicles, miRNA, biomarker, early diagnosis, progrosis”in Chinese and English, respectively. Total y 50 eligible articles were included in result analysis. <br> RESULTS AND CONCLUSION:After reviewing researches of exosomes in different diseases, we can confirm that exosomes broadly participant in physiological and pathological process of various system diseases. The abnormal expression of exosomal micro-RNAs has been identified in many studies, indicating the exosomal micro-RNAs have a great potential to be biomarkers for disease diagnosis. Further studies should focus on extracting the contents of exosomes, the pathogenesis of exosomes is involved in and screening the appropriate exosomal miRNAs for early diagnosis.关键词
组织构建/组织工程/外泌体/miRNA/生物标志物/疾病诊断/蛋白质/DNA/RNA/肿瘤/血管/神经分类
医药卫生引用本文复制引用
李毅,唐佩福..外泌体中Micro-RNA可作为疾病的生物标志物？[J].中国组织工程研究,2016,20(51):7738-7745,8.基金项目
国家自然青年科学基金项目(81401809)Funding:the National Natural Science Foundation for the Youth of China, No.81401809 （81401809）
