中国组织工程研究2016，Vol.20Issue(51)：7746-7752,7.DOI:10.3969/j.issn.2095-4344.2016.51.022
牙周炎与p38丝裂原活化蛋白激酶通路的研究与进展
Periodontitis and p38 mitogen activated protein kinase pathway:research and development
摘要
Abstract
BACKGROUND:A series of inflammatory signal pathways are activated accompanied by increasing expressions of inflammatory factors after periodontal tissues being stimulated by exogenous substances like bacterium. Inflammation is closely related to periodontal tissue repair and regeneration. <br> OBJECTIVE:To il ustrate the correlation of immune response of periodontitis and periodontitis-related inflammatory cytokines to p38 mitogen activated protein kinase (p38MAPK) pathway, and to provide a new idea and method for the treatment of periodontitis in the future. <br> METHODS:The related literatures of periodontitis and p38MAPK pathway published from January 1990 to January 2016 were retrieved from the databases of CBM, CNKI, SWIC and PubMed. The research and progress of periodontal tissue repair and regeneration after periodontitis were analyzed. <br> RESULTS AND CONCLUSION:Total y 36 literatures were enrol ed final y. Inflammation-regulated and inflammation-associated signaling pathways as wel as subsequent expression of inflammatory mediators can partly control the excessive disease-induced inflammation and immune responses of the host, among which p38MAPK signaling pathway may be involved in the occurrence and development of periodontitis. More studies, however, are needed to validate these findings. The regulation of p38MAPK signaling pathway is stil of great significance in the treatment of periodontal disease, and we hope to provide a new insight and basis for clinical diagnosis and treatment of periodontitis.关键词
组织构建/组织工程/牙周炎/p38丝裂原活化蛋白激酶/肿瘤坏死因子/白细胞介素1/核因子κB受体活化因子配体/牙周膜干细胞/阻断剂/炎症/免疫/修复分类
医药卫生引用本文复制引用
唐亚平,刘琪,郭成伟,谢瑞娣..牙周炎与p38丝裂原活化蛋白激酶通路的研究与进展[J].中国组织工程研究,2016,20(51):7746-7752,7.基金项目
国家自然科学基金(81360168)Funding:the National Natural Science Foundation of China, No.81360168 （81360168）
