医药导报2017，Vol.36Issue(1)：44-47,4.DOI:10.3870/j.issn.1004-0781.2017.01.010
西地那非超说明书用药回顾性调查
Off-label Use of Sildenafil:A Retrospective Survey
邓贵华 1杨亮 1陈小葵 1何敬华 1张琳1
作者信息
- 1. 广东省妇幼保健院药学部,广州 511400
- 折叠
摘要
Abstract
Objective To understand the situation of off-label use of sildenafil, so as to provide reference for developing off-label drug use policy. Methods A stratified random sampling method was used to collect prescription data of sildenafil in Guangdong Women and Children Hospital in 2015. The off-label drug use situation was analyzed according to drug labels. The situations of drug use in all departments were summarized, and off-label drug use occurrences were analyzed.Results A total of 1044 prescriptions with sildenafil were collected and analyzed to discover the occurrence of off-label use was up to 69. 54%. The top 3 departments of off-label use of sildenafil were assisted reproductive center, heart center and neonatal intensive care unit (NICU). The top 3 types of off-label use were non-indication(50. 35%), over drug population(31. 76%) and over drug administration(17. 89%). The top 3 diseases for non-indications were infertility, pulmonary hypertension and congenital heart disease. Conclusion Sildenafil off-label use was common in Guangdong Women and Children Hospital in 2015, especially in assisted reproductive center, heart center, and NICU. The result suggests that more clinical studies about sildenafil on cardiovascular system are expected to provide more evidence for drug use, so as to ensure the safety of drug use in special populations and avoid potential medical risk.关键词
西地那非/超说明书用药/用药分析/合理用药Key words
Sildenafil/Off-label use/Drug analysis/Rational drug use分类
医药卫生引用本文复制引用
邓贵华,杨亮,陈小葵,何敬华,张琳..西地那非超说明书用药回顾性调查[J].医药导报,2017,36(1):44-47,4.
