诊断学理论与实践2016，Vol.15Issue(6)：578-581,4.DOI:10.16150/j.1671-2870.2016.06.007
速激肽受体2对小鼠溃疡性结肠炎的影响
Influence of Tacr2 on ulcerative colitis in mice
摘要
Abstract
Objective: Using Tacr2 (tachykinin receptor 2) gene knockout mice and induction of ulcerative colitis (UC) to study the influence and mechanism of Tacr2 on development of ulcerative colitis (UC). Methods Tacr2 knockout mice and wild type mice were treated with oral dextran sodium sulfate (DSS)solution for a week to induce UC, non-treated Tacr2 knockout mice and wild type mice were served as blank controls. Activity index and pathological change of colonic mucosa were studied, and the inflammation score, NF-κB expression in colonic tissue were detected. Results Tacr2 knockout mice showed higher susceptibility to DSS solution. When compared with wild type mice, Tacr2 knockout mice had a significantly decreased level of immunocompetence , presenting with decreased levels of IL-1β, TNF-α, IL-6 and NF-κB. Conclusions Tacr2 has an inhibitory effect on the development of ulcerative colitis in mice.关键词
溃疡性结肠炎/速激肽受体2/小鼠模型Key words
Ulcerative colitis/Tachykinin receptor 2/Mouse models分类
医药卫生引用本文复制引用
毛钰蕾,周涛,唐凌云,张洪信,王铸钢..速激肽受体2对小鼠溃疡性结肠炎的影响[J].诊断学理论与实践,2016,15(6):578-581,4.基金项目
国家自然科学基金 （）
