中风与神经疾病杂志2016，Vol.33Issue(12)：1084-1086,3.
线粒体脑肌病伴高乳酸血症和卒中样发作综合征的影像学特征及动态演变
Features and dynamic evolution of imaging in mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome
摘要
Abstract
Objective To investigate the features and dynamic evolution of imaging in mitochondrial encephalomy-opathy with lactic acidosis and stroke-like episodes ( MELAS) syndrome.Methods The data of 21 cases of MELAS syn-drome diagnosed by muscle biopsy in our hospital from January 2011 to February 2016 were collected ,and the neuroimaging of CT,MRI,enhanced MRI ,MRA and MRS were retrospectively analyzed .Results 8 cases showed bilateral basal ganglia calcification symmetry in 19 patients who underwent head CT scan .The abnormal areas showed low signal intensity on T1 WI,high signal intensity on T 2 WI and FLAIR,high or equal signal intensity on DWI ,high or low signal intensity on ADC in stroke-like episodes;the NAA peak was decreased and lactate peak was significantly increased on MRS .19 cases (90.5%) were involved in 2 and more than 2 lobes,and the most frequently involved parts of the lesion were occipital ,tem-poral and parietal lobe .The lesions were lamellar necrosis ,and the distribution was not in accordance with the control region of the cerebral vessels .Dynamic observation revealed that the lesions were reversible ,migratory and progressive .Conclusion MELAS syndrome had complex clinical manifestations ,and the neuroimaging had certain characteristics and important di-agnostic value .Fully understanding these characteristics will help to make early diagnosis and treatment , also reduce the misdiagnosis .关键词
线粒体脑肌病伴高乳酸血症和卒中样发作综合征/计算机断层扫描/磁共振/特征Key words
MELAS syndrome/Computed tomography/Magnetic resonance imaging/Features分类
临床医学引用本文复制引用
吴世陶,刘恒方,刘方,张敏,陈宁宁,郭亚培,王建平..线粒体脑肌病伴高乳酸血症和卒中样发作综合征的影像学特征及动态演变[J].中风与神经疾病杂志,2016,33(12):1084-1086,3.基金项目
河南省科技厅科技攻关项目 （）
