中国感染控制杂志2016，Vol.15Issue(12)：897-901,5.DOI:10.3969/j.issn.1671-9638.2016.12.001
社区获得性耐甲氧西林金黄色葡萄球菌SCCmec基因分型及药敏结果
SCCmec genotyping and antimicrobial susceptibility of community-ac-quired methicillin-resistant Staphylococcus aureus
摘要
Abstract
Objective To investigate the types of staphylococcal cassette chromosome mec (SCCmec)gene and an-timicrobial resistance of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA)isolated from outpatients and inpatients in a hospital.Methods MRSA strains isolated between May 2011 and August 2015 in a hospi-tal and the relevant case data were collected,polymerase chain reaction(PCR)method was used to identify mecA gene of MRSA and SCCmec gene of CA-MRSA,antimicrobial susceptibility testing of CA-MRSA were performed and analyzed. Results A total of 305 MRSA isolates were collected,296 of which were mecA positive,29.73% (88/296)were CA-MR-SA. The genotyping of CA-MRSA showed that 48 strains were SCCmec type Ⅳ,36 were SCCmec type V,the other 4 strains were undefined. Antimicrobial susceptibility testing results showed that susceptibility rates of CA-MRSA to vanco-mycin,linezolid,and tigecycline were all 100% ,resistance rates to penicillin and oxacillin were both 100% ;resistance rates of SCCmec type IV and SCCmec type V CA-MRSA strains to levofloxacin,rifampicin,and ciprofloxacin were all signifi-cantly different (all P<0.05),to ampicillin/sulbactam,furantoin,and erythromycin were all >58% .Conclusion The main SCCmec type of CA-MRSA are type IV and type V in this hospital,antimicrobial resistance rate is high,clinicians should pay high attention,and use antimicrobial agents according to antimicrobial susceptibility testing results.关键词
金黄色葡萄球菌/社区获得性耐甲氧西林金黄色葡萄球菌/CA-MRSA/SCCmec基因分型/抗药性,微生物/耐药性/合理用药Key words
Staphylococcus aureus/community-acquired methicillin-resistant Staphylococcus aureus/CA-MR-SA/SCCmec genotyping/drug resistance,microbial/rational antimicrobial use分类
医药卫生引用本文复制引用
牛瑞兵,郭利平,王新刚,段宝生,巴特尔..社区获得性耐甲氧西林金黄色葡萄球菌SCCmec基因分型及药敏结果[J].中国感染控制杂志,2016,15(12):897-901,5.基金项目
内蒙古自治区自然科学基金面上项目（2013MS1116）；内蒙古自治区卫生和计划生育委员会医疗卫生科研计划项目 （）
