中国现代医学杂志2016，Vol.26Issue(24)：1-5,5.DOI:10.3969/j.issn.1005-8982.2016.24.001
负压封闭引流技术对兔创面超敏CRP和纤维连接蛋白的影响
Effect of vacuum sealing drainage on C-reactive protein and fibronectin level in rabbit model of surface wound
摘要
Abstract
Objective To investigate changes in serum levels of hypersensitive C-reative protein (hs-CRP) and fibronectin (Fn) before and after Vacuum Sealing Drainage (VSD) applied on wound surface in a rabbit model. Methods Surface wounds were created in 16 rabbits, which were randomly assigned to control group ( = 8; normal aseptic care and regular dressing changes) and VSD group. Venous samples were obtained at baseline (0 hr) , 6 hrs, 12 hrs, 1 d, 3 d, 5 d and 7 d after the injury. Levels of hs-CRP and Fn were compared between groups. Results There was no difference of hs-CRP and Fn levels between two groups at baseline. Beginning at 12 hrs after injury, levels of hs-CRP in VSD group were consistently and significantly higher than that in the control group ( < 0.05). The level of hs-CRP peaked at day 1 in the VSD group (43.81 ± 3.15 mg/L) compared with day 3 in the control group (70.84 ± 4.82 mg/L). Beginning from day 1, levels of Fn were significantly higher in the VSD group than that in the control group. Fn levels peaked at day 3 in both groups (161.53 ± 8.60 mg/L vs 109.83 ± 9.18 mg/L), but Fn level in the VSD group remained elevated after that and declined smoothly. Conclusions VSD technique is able to drain debris and exudates from surface wound, improve microcirculation and fibroblast proliferation, also decrease serum hs-CRP level while increasing Fn level, thereby attenuate inflammatory response, which in turn improves wound healing.关键词
负压封闭引流/超敏C-反应蛋白/纤维连结蛋白Key words
vacuum sealing drainage/hypersensitive C-reactive protein/fibronectin分类
医药卫生引用本文复制引用
林伟文,赖茂松,黄瑞良,熊浩,罗鹏刚,夏雄超,凌华军,吴增志,钟萍..负压封闭引流技术对兔创面超敏CRP和纤维连接蛋白的影响[J].中国现代医学杂志,2016,26(24):1-5,5.基金项目
2015年广东省佛山市卫生局科研立项项目 （）
