Abstract
Objective To investigate the influence of oxidative stress-related enzymes and signal pathway protein expression on arteriovenous fistula (AVF) in patients with thrombosis. Methods From January 2014 to January 2016, 120 patients treated with routine arteriovenous fistula (AVF) or AVF repair surgery were divided into two groups according whether AVF thrombosis occurred after surgery: A group of 71 cases (AVF thrombosis after surgery), group B had 49 cases (AVF postoperative thrombosis). Levels of blood biochemical marker, oxidative stress-related enzymes (SOD-1, SOD-2, HO-1, Rac- 2 and NOX-4) and related signaling pathway proteins (P-22, P13K, P-Fox01 and P-Fox03a) were compared. Results Levels ofplasma parathyroid hormone, homocysteine in group Awere significantly higher than group B ( = 0.000, 0.000), and hemoglobin, C-reactive protein levels were significantly lower than group B, the differences were significant ( =0.000, 0.000). Levels of SOD-1, SOD-2, HO-1, Rac-2 and NOX-4 in group A were significantly higher than group B, the differences were statistically significant ( = 0.000, 0.000, 0.000, 0.000, 0.000).Levels of P-22, P13K, P-Fox01 and P-Fox03a in vastular tissue of group A were higher than group B, the differences were significant ( = 0.000, 0.000, 0.000, 0.000). Fistula thrombosis in patients with vascular tissue were significantly correlated with SOD-1, SOD-2, HO-1, Rac-2, NOX-4, P-22, P13K, P-Fox01 and P-Fox03a levels ( = 0.040, 0.010, 0.041, 0.022, 0.030, 0.021, 0.031, 0.020, 0.021). Conclusions The oxidative stress expresses protein associated enzymes by P13K/Fox0 signal transduction pathway, causes endothelial damage, leads to stenosis of arteriovenous fistula and anastomosis thrombosis. Clinical intervention by the stress response can move fistula patients intravenously and in vivo signaling pathway associated protein expression in the formation of prevention or treatment of arteriovenous fistula thrombosis.关键词
氧化应激/信号通路蛋白/动静脉内瘘/血栓Key words
oxidative stress/signal pathway protein/arteriovenous fistula/thrombus分类
医药卫生
