中国药理学通报2016，Vol.32Issue(12)：1629-1633,1634,6.DOI:10.3969/j.issn.1001-1978.2016.12.001
TGF-βⅢ型受体介导的信号通路及其在纤维化疾病中的作用
Type Ⅲ TGF-βreceptor mediated signaling pathway and its role in fibrotic diseases
摘要
Abstract
Transforming growth factor β(TGF-β)superfamily ligands play an important role in regulating cellular homeostasis including proliferation,differentiation,apoptosis,immune sur-veillance and angiogenesis.Type Ⅲ TGF-βreceptor (TβRⅢ) is considered to be the coreceptor of TGF-βsuperfamily.TβRⅢnot only has an effect on classical Smad signaling pathway,but also on non-Smad signaling pathway.TβRⅢplays a crucial role in fibrosis,tumor,cardiovascular diseases via mediating kinds of signaling pathways.This paper reviews TβRⅢ mediated sig-naling pathway and its role in fibrotic diseases.关键词
TGF-βⅢ型受体/纤维化疾病/信号通路/β-arrestin2/Smad/MAPKKey words
type Ⅲ TGF-βreceptor/fibrotic diseases/signa-ling pathway/β-arrestin2/Smad/MAPK引用本文复制引用
厉歆然,孙妩弋,谷元婧,彭文婷,魏伟..TGF-βⅢ型受体介导的信号通路及其在纤维化疾病中的作用[J].中国药理学通报,2016,32(12):1629-1633,1634,6.基金项目
国家自然科学基金资助项目（No 81300332，81673444，81330081）；安徽省高等学校省级自然科学研究项目 （）
