中国药理学通报2016，Vol.32Issue(12)：1634-1638,5.DOI:10.3969/j.issn.1001-1978.2016.12.002
CCL2／MCP-1在其相关疾病的机制研究
Mechanism of CCL2/MCP-1 in its relevant diseases
摘要
Abstract
Chemokine is a small protein which plays an impor-tant role in men's physiological function.It has chemotactic ac-tivity and is often secreted by immune cells and glial cells like microglia or astrocytes.Through the effect of chemokine recep-tors on target cells,various immune cells can achieve directional migration and play an important role in the diseases related with immunity and inflammation.CCL2,also known as monocyte chemotactic protein-1 (MCP-1 ),is one member of chemokine CC subfamily (βsubfamily).It can chemokine monocytes, macrophages and T lymphocytes to affect their phagocytosis func-tion and produce antibodies to combat invading microorganisms. In recent years,it has been found that CCL2 plays a key role in the occurrence and development of the problems concerning cen-tral nervous system and immune system as well as cancer, AIDS,leukemia,diabetes and other diseases.This thesis is to give an elaboration on the latest research on CCL2 and the rele-vant diseases.关键词
趋化因子/CCL2/受体/单核细胞/免疫系统/肿瘤/神经疾病Key words
chemokines/CCL2/receptor/monocytes/immu-nity system/cancer/nerve disease引用本文复制引用
姜懿纳,陈乃宏..CCL2／MCP-1在其相关疾病的机制研究[J].中国药理学通报,2016,32(12):1634-1638,5.基金项目
国家自然科学基金资助项目（No 81373997）；北京市自然科学基金资助项目 （）
