中国药理学通报2016，Vol.32Issue(12)：1639-1642,1643,5.DOI:10.3969/j.issn.1001-1978.2016.12.003
多药及毒素外排转运蛋白遗传药理学研究进展
Research progress on pharmacogenetics in multidrug and toxin extrusion proteins
摘要
Abstract
The body is equipped with kinds of transporters which generally exist in liver,kidney,and intestine.Multidrug and toxin extrusion proteins(MATEs;SLC47A)are predominantly expressed in the brush-border membrane of proximal tubule epi-thelial cells in the kidney and the canalicular membrane of hepa-tocytes.Functionally,MATEs act as efflux transporters for or-ganic compounds.The article discusses type,structure,poly-morphism and function of MATE1and MATE2-K,and also dis-cusses the effect of single nucleotide polymorphisms (SNPs)in the SLC47A1 gene and SLC47A2 on the pharmacokinetics and pharmacodynamics of metformin and platinum-based chemothera-peutic agents.关键词
多药及毒物外排蛋白/单核苷酸多态性/二甲双胍/顺铂/糖尿病/副作用Key words
multidrug and toxin extrusion proteins/SNP/met-formin/cisplatin/diabetes/side efect引用本文复制引用
熊宗萍,朱鹏,黄师琼,李清..多药及毒素外排转运蛋白遗传药理学研究进展[J].中国药理学通报,2016,32(12):1639-1642,1643,5.基金项目
国家自然科学基金资助项目 （）
