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丹参酮类化合物研究进展

刘慧颖 姜长涛 冯娟 王宪

中国药理学通报2016,Vol.32Issue(12):1643-1647,5.
中国药理学通报2016,Vol.32Issue(12):1643-1647,5.DOI:10.3969/j.issn.1001-1978.2016.12.004

丹参酮类化合物研究进展

Research progress of Tanshinones

刘慧颖 1姜长涛 1冯娟 1王宪1

作者信息

  • 1. 北京大学医学部基础医学院生理学与病理生理学系,北京 100191
  • 折叠

摘要

Abstract

Salvia miltiorrhiza bunge (Dan shen in Chinese)is extracted from dried roots and rhizomes of Labiatae Salvia.Tan-shinones are the main lipid-soluble components in Salvia,each has specific pharmacological activity.This review focuses on the research progress of Tanshinones on cardiovascular diseases,an-ti-inflammatory and immunomodulatory effects, anti-tumor effect,hepatocyte protection and neuroprotective effects.Thera-peutic effects and mechanisms of Tanshinones on diverse disea-ses are summarized,pharmacokinetics and pharmaceutic evalua-tion were concluded.This review provides a global understand-ing about Tanshinones as a class of effective and promising can-didates for further studies,and lays a foundation for developing new Tanshinone-based agents according to the characteristics of Tanshinones.

关键词

丹参酮/临床应用/药理作用/药效机制/药代动力学/制剂评价

Key words

Tanshinones/clinical appacation/pharmacologic effects/therapeutic mechanism/pharmacokinetics/pharmaceutic evaluation

引用本文复制引用

刘慧颖,姜长涛,冯娟,王宪..丹参酮类化合物研究进展[J].中国药理学通报,2016,32(12):1643-1647,5.

基金项目

国家优秀青年科学基金资助项目 ()

中国药理学通报

OA北大核心CSCDCSTPCD

1001-1978

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