中国医学科学院学报2016，Vol.38Issue(6)：627-631,5.DOI:10.3881/j.issn.1000-503X.2016.06.001
不同剂量的右美托咪定术前经鼻雾化给药对小儿喉罩置入时七氟醚 EC50的影响
Effects of Two Intranasal Dexmedetomidine Doses as Premedication on Sevoflurane EC50 for Successful Laryngeal Mask Airway Placement in Children
徐瑾 1邓晓明 1魏灵欣 1杨冬 1刘具会 1郅娟 1李亚男1
作者信息
- 1. 中国医学科学院 北京协和医学院 整形外科医院麻醉科，北京100144
- 折叠
摘要
Abstract
Objective To observe the effects of two different intranasal dexmedetomidine doses as premedication on the EC50 of sevoflurane for successful laryngeal mask airway placement in children. Methods Children aged 3-6 years, of American Society of Anesthesiologists physical statusⅠ, and scheduled for plas-tic surgery were enrolled in this study. Children were assigned to receive either spray administration of in-tranasal dexmedetomidine 1 μg/kg ( group D1 , n=21 ) or 2 μg/kg ( group D2 , n=20 ) approximately 30 mi-nutes before anesthesia. Anesthesia was induced with sevoflurane up to 8% in 100% O2 , with fresh gas flow set to 6 L/min. After the pupil fixed to the middle position, sevoflurane dial setting was reduced to 5% and fresh gas flow reduced to 3 L/min. The endtidal sevofluran (ETsevo) concentration for laryngeal mask airway in-sertion sustained for 10 minutes after vein intubation, which was determined according to the Dixon’ s up and down method. The initial endtidal sevoflurane concentration in each group was set at 2%. ETsevo was increased/decreased (1 ∶1. 2) in the next patient according to the response to laryngeal mask airway insertion. Bispectral index, mask acceptance, all response to laryngeal mask airway insertion, and ETsevo of laryngeal mask airway insertion of children were recorded. Results The bispectral index value was 77. 4 ± 3. 6 in group D2 , which was significantly lower than that (87. 4±1. 9) in group D1 when children entered operation room (P<0. 05). Mask acceptance was 76. 2% in group D1 and 90. 0% in group D2. The EC50 of sevoflurane for laryngeal mask airway insertion was 1. 09% (95% CI=0. 89%-1. 28%) in group D2, which was lower than 1. 59% (95%CI=1. 41%-1. 78%) in group D1 ( P<0. 05 ) . Conclusion Compared with the dose of 1 μg/kg, spray ad-ministration of intranasal dexmedetomidine 2 μg/kg as premedication can reduce the sevoflurane EC50 for suc-cessful laryngeal mask airway placement in children.关键词
右美托咪定/经鼻雾化给药/小儿/七氟醚EC50Key words
dexmedetomidine/spray administration of intranasal/child/EC50 of sevoflurane分类
医药卫生引用本文复制引用
徐瑾,邓晓明,魏灵欣,杨冬,刘具会,郅娟,李亚男..不同剂量的右美托咪定术前经鼻雾化给药对小儿喉罩置入时七氟醚 EC50的影响[J].中国医学科学院学报,2016,38(6):627-631,5.
