中国医学科学院学报2016，Vol.38Issue(6)：666-678,13.DOI:10.3881/j.issn.1000-503X.2016.06.008
氯氮平治疗难治性精神分裂症的优化治疗方案
Optimal Treatment Strategies of Clozapine for Refractory Schizophrenia
摘要
Abstract
Objective To systematically evaluate the efficacy of clozapine combined with other antipsy-chotic drugs in the treatment of refractory schizophrenia. Methods We searched Medline, EMBASE, and China Biology Medicine databases in both English and Chinese for randomized controlled trials, quasi-randomization controlled trials, and clinical controlled trials concerning the combinations of clozapine with other antipsychotic drugs for refractory schizophrenia. Quality assessment and data extraction were conducted with the Cochrane col-laboration’ s RevMan 5. 3 software. Results Totally 47 trials met the inclusion criteria, in which clozapine was combined with risperidone, aripiprazole, sulpiride, ziprasidone, modified electroconvulsive therapy, valproate, or lithium carbonate, respectively. Analysis showed that most combination strategies were superior to clozapoine alone ( P<0. 05 ) , except for the combination with lithium carbonate ( 8 weeks: RR=1. 27 , 95%CI=0. 82-1. 97 , P=0. 28;12 weeks:RR=1. 53 , 95% CI=0. 45-5. 13 , P=0. 49 ) . Conclusion Reasonable combi-nation of clozapine with other drugs may improve the therapeutic effectiveness and reduce adverse reactions and <br> hus can be effectively used for treating refractory schizophrenia.关键词
氯氮平/难治性精神分裂症/有效性/Meta分析Key words
clozapine/refractory schizophrenia/efficacy/Meta-analysis分类
医药卫生引用本文复制引用
李媛媛,张云淑,王健,栗克清,王红英..氯氮平治疗难治性精神分裂症的优化治疗方案[J].中国医学科学院学报,2016,38(6):666-678,13.基金项目
河北省青年基金(20120254) Supported by the Youth Fund Project of Hebei Province (20120254) （20120254）
