中国医学科学院学报2016，Vol.38Issue(6)：679-685,7.DOI:10.3881/j.issn.1000-503X.2016.06.009
增强型准连续动脉自旋标记灌注成像技术对重度颅内粥样硬化性狭窄低灌注定量测量
Quantitative Measurement of Cerebral Blood Flow in Enhanced Psedo-continuous Arterial Spin Labeling Perfusion Imaging in Patients with Intracranial Atherosclerotic Stenosis
摘要
Abstract
Objective To acquire cerebral blood flow ( CBF) in patients with severe intracranial ather-osclerotic stenosis with enhanced pseudo-continuous arterial spin labeling ( e-pCASL ) and compare it with the findings of dynamic susceptibility contrast-enhanced perfusion-weighted imaging ( DSC PWI) and pseudo-continu-ous arterial spin labeling ( pCASL) . Methods A total of 39 consecutive patients with severe intracranial ather- <br> osclerotic stenosis were enrolled in this study. All these patients underwent e-pCASL, pCASL, and DSC PWI. Blood supply territory of the stenosed artery was outlined as region of interest ( ROI) and a mirror ROI was ap-plied. Ratios of CBF were calculated as value of ROI/value of mirror ROI. SNK variance analysis was conducted to compare the CBF values of three persufion methods. Factorial analysis of variance and Pearson were employed to analysis the difference and the correlation of e-pCASL CBF ratio, pCASL CBF ratio, and DSC PWI relative cerebral blood flow ( rCBF) ratio. Results The e-pCASL CBF ratio, pCASL CBF ratio, and DSC PWI rCBF ratio were not significantly different ( P=0. 476 ) . TTP showed the CBF ratios were not significantly different be-tween the healthy side and diseased side in patients with severe intracranial atherosclerotic stenosis. ATT showed the correlations of pCASL CBF ratio and DSC PWI rCBF ratio were not affected by ATT. Conclusions e-pCASL with multiple-post labeling delay time and pCASL have good consistency with DSC PWI in the quantitative meas-urement of hypoperfusion pattern. As an accurate, simple, non-invasive, and repeatable technique, e-pCASL has good correlation with DSC PWI in the quantitative measurement of hypoperfusion pattern that is not affected by ATT.关键词
动脉到达时间/颅内动脉粥样硬化性狭窄/动态磁敏感加权灌注成像/连续性动脉自旋标记灌注成像Key words
arterial transit time/severe intracranial atherosclerotic stenosis/dynamic susceptibility contrast-enhanced perfusion-weighted imaging/pseudo-continuous arterial spin labeling分类
医药卫生引用本文复制引用
许洋,吕晋浩,马林,陈为军,娄昕..增强型准连续动脉自旋标记灌注成像技术对重度颅内粥样硬化性狭窄低灌注定量测量[J].中国医学科学院学报,2016,38(6):679-685,7.基金项目
国家自然科学基金(81101034) Supported by the National Natural Sciences Foundation of China (81101034) （81101034）
