中国医学科学院学报2016，Vol.38Issue(6)：706-709,4.DOI:10.3881/j.issn.1000-503X.2016.06.013
系统性淀粉样变患者诊断性活检部位的选择
Selection of Biopsy Site for Patients with Systematic Amyloidosis
摘要
Abstract
Objective To evaluate the sensitivities of various biopsy methods for the diagnosis of sys-tematic amyloidosis ( SA) . Methods The clinical data and biopsy results of 194 SA patients who were treated in Peking Union Medical College Hospital from January 2009 to June 2015 were retrospectively analyzed. Results The highest sensitivity was achieved by biopsy of affected organs, with renal biopsy 97. 4%, heart biopsy 95. 0% and liver biopsy 87. 5%. Among non-invasive biopsy methods, tongue biopsy was found to be 75% sen-sitive, followed by gingiva biopsy at 57%, abdominal fat pad aspiration at 57%, rectum biopsy at 16%, and bone marrow examination at 8%. Combination of tongue and abdominal fat pad biopsy yielded a detection rate of 93. 1%. Conclusions Biopsy of the involved organ has the highest sensitivity. However, combination of multi-ple non-invasive biopsy methods may has sensitivity comparable to organ biopsy and is safer and more convenient.关键词
系统性淀粉样变/刚果红染色/活检Key words
systematic amyloidosis/Congo red stain/biopsy分类
医药卫生引用本文复制引用
张春兰,冯俊,曹欣欣,张聪丽,沈恺妮,黄栩芾,张路,周道斌,李剑..系统性淀粉样变患者诊断性活检部位的选择[J].中国医学科学院学报,2016,38(6):706-709,4.基金项目
首都临床特色应用研究(Z131107002213050) Supported by the Capital Clinical Characteristic Application Project (Z131107002213050) （Z131107002213050）
