摘要
Abstract
Objective To investigate the clinical efficacy of percutaneous endoscopic lumbar discectomy treatment for elderly patients with lumbar disc herniation and its effect on matrix metalloproteinase-9 (MMP-9). Method From December 2013 to October 2015, 116 cases of elderly patients with lumbar disc herniation in our hospital were randomly divided into research group and control group, 58 cases in each group. Control group patients were treated with microscopic discectomy, research group patients were treated with percutaneous transforaminal technique discectomy. The MMP-9 and TIMP-1 expression level of nucleus pulposus tissue of two groups were tested by Western blotting method. The operation time, incision length, fluoroscopy time, hospital stay, unable to work time, MMP-9 level, TIMP-1 level, VAS score and Oswestry disability index of the two groups were compared. Result The operation time, fluoroscopy time of research group were longer than control group (P < 0.05), while incision length, hospital stay time, unable to work time were shorter (P < 0.05). There were no significant differences in VAS score and Oswestry disability index between the two groups before surgery (P > 0.05). After surgery, VAS score and Oswestry disability index of both groups decreased significantly (P < 0.05). 1 month and 3 months after surgery, the VAS score and Oswestry dability index of research group were lower than control group (P < 0.05). 3 months after surgery, Pfirrmann classification of research group was better than control group (P < 0.05). There were no significant differences in MMP-9 and TIMP-1 level between the two groups (P > 0.05). Conclusion Percutaneous endoscopic lumbar discectomy surgery has exact effect for lumbar disc herniation. It does well in reducing painful and promoting the rehabilitation after surgery.关键词
经皮椎间孔镜/腰椎间盘突出症/基质金属蛋白酶Key words
Percutaneous endoscopic lumbar discectomy/Lumbar disc herniation/Matrix metalloproteinase
