中国医药科学2016，Vol.6Issue(19)：40-43,4.
化橘红对大鼠糖尿病心肌病的防治作用及其机制研究
Prevention and cure effect of xocarpium Citri Grandis in diabetic cardiomyopathy rats and its mechanisms
摘要
Abstract
Objective To investigate prevention and cure effect of of exocarpium citri grandis (ECG) in streptozocin-induced diabetic cardiomyopathy (DCM) rats and its mechanisms.Methods Sprague-Dawley (SD) Rats were divided into DCM group,control group,ECG group (low, medium, high dose),pioglitazone group.After intragastric administration with different concentrates of ECG,myocardial histopathologic changes were measured using haematoxylin and eosin staining,p 38MAPK and cleaved caspase-3 levels were tested through Western blot assay.Ultrastructure of myocardial tissues were detected by means of electron microscopy.Results Compared with control group,myocardial cells apoptosis,hypertrophy,collagen deposit and ultrastructural changes in heart tissues were exacerbated,administration with ECG improved these injured alternations and inhibited expressions of p-p38 MAPK and cleaved caspase-3.ConclusionECG can prevent and treat diabetic cardiomyopathy myocardial structural damage.Its mechanisms might mediate by p 38MAPK signal pathway.关键词
化橘红/p38 MAPK/糖尿病心肌病/凋亡Key words
Exocarpium citri grandis/p38 MAPK/Diabetic cardiomyopathy/Apoptosis分类
医药卫生引用本文复制引用
郭润民,吴铿,吴子君,黄瑞娜,刘畅,梁国标,李上海,莫海亮,闫海,游琼..化橘红对大鼠糖尿病心肌病的防治作用及其机制研究[J].中国医药科学,2016,6(19):40-43,4.基金项目
国家自然科学基金（81670348）；广东省重大科技专项（2012A080202020）；广东省湛江市科技计划项目(2014A01033)。 （2014A01033）
