中国医药科学2016，Vol.6Issue(19)：44-47,4.
二苯乙烯苷对氟中毒所致动脉粥样硬化的保护作用及机制研究
Protective effect of two styrene glycosides to atherosclerosis due to fluorosis and its mechanism
摘要
Abstract
ObjectiveTo explore the protective effect of two styrene glycosides to atherosclerosis due to fluorosis and its mechanism.Methods 60 healthy New Zealand white rabbits were randomly divided into normal control group, model group, positive control group,two styrene glycosides low dose group (low dose group),two styrene glycosides middle dose group (middle dose group),two styrene glycosides high dose group(high dose group) with 10 rabbits in each group.Rabbits in normal control group and model group were givedn the same volume distilled water, rabbits in positive control group were given probucol 250mg/(kg·d),rabbits in low dose group were given probucol 30mg/(kg·d),rabbits in middle dose group were given probucol 60mg/(kg·d),and rabbits in high dose group were given probucol 120mg/(kg·d).Pathological change of the rabbits in each group were observed, and serum lipid levels and plasma apoA1/apoB100 ratio of each group were detected.Results Compared with the normal control group,the TC,TG,LDL-C,HDL-C level of other group were significantly decreased (P<0.05). Compared with the model group,the TC,TG,LDL-C,HDL-C level of positive control group, low dose group, middle dose group, high dose group were significantly decreases (P<0.05).Compared with the positive control group,the TC,TG,LDL-C,HDL-C level of high dose group were significantly decreases (P<0.05).Compared with the normal control group, the plasma ratio apoA1/apoB100 of other group were significantly decreased (P<0.05).Compared with the model group, the plasma ratio apoA1/apoB100 of positive control group, low dose group, middle dose group, high dose group were significantly increases (P<0.05).Compared with the positive control group, the plasma ratio apoA1/apoB100 of high dose group were significantly increases (P<0.05).Compared with the low dose group and middle dose group, the plasma ratio apoA1/apoB100 of high dose group were significantly increases (P<0.05). ConclusionTwo styrene glycosides to atherosclerosis due to fluorosis has a certain protective effect. The mechanism may be related to the regulation of serum lipids and the increase of apoA1/apoB100 ratio in plasma.关键词
二苯乙烯苷/氟中毒/动脉粥样硬化/保护作用/机制研究Key words
Two styrene glycosides/Fluorosis/Atherosclerosis/Protective effect/Mechanism study分类
医药卫生引用本文复制引用
吴晓玲,张贵锋,刘其礼,保泽庆..二苯乙烯苷对氟中毒所致动脉粥样硬化的保护作用及机制研究[J].中国医药科学,2016,6(19):44-47,4.基金项目
广东省肇庆市科技创新计划项目（2016040301-50）。 （）
