中国医药科学2016，Vol.6Issue(19)：52-54,3.
脂氧素A4对大鼠肺缺血再灌注损伤氧化损伤的影响
Influence of lipoxin A4 administration on oxidative injury induced by lung ischemia reperfusion in rats
摘要
Abstract
Objective To investigate the influence of lipoxin A4 administration on oxidative stress after lung ischemia reperfusion injury in rats.Methods36 male S-D rats, weighing 220-280g,were randomly divided into sham-operation group (group S), the lung ischemia reperfusion group (group IR) and the lipoxin A4 administration group (group LX). 45min ischemia was induced by occluding the hilum of the left lung,followed by a 2h reperfusion by removing occlusion of the hilum, lipoxinA4 (0.1mg/kg) was injected intravenously 5 min before reperfusion in group LX. Lung tissues and BALF were collected. W/D, TP in BALF, malondialdehyde (MDA) and superoxide dismutase (SOD) were determined 2h after reperfusion.Results Compared with group S, W/D and MDA in lung tissue and TP in BALF were significantly increased, while the SOD activities were significantly decreased in group IR (P<0.05). Compared with group IR, W/D and MDA in lung tissue and TP in BALF were significantly decreased, while the SOD activities were significantly increased in group LX (P<0.05).Conclusion Lipoxin A4 administration has the protective effect on lung ischemia reperfusion injury, and the mechanism may be related to scavenging free radicals.关键词
脂氧素A4/氧自由基/氧化损伤/肺缺血再灌注损伤Key words
Lipoxin A4/Oxygen free radical/Oxidative injury/Lung ischemia reperfusion injury分类
医药卫生引用本文复制引用
李春来,刘永梁,李洪志,袁晓环,李兴旺,刘再英..脂氧素A4对大鼠肺缺血再灌注损伤氧化损伤的影响[J].中国医药科学,2016,6(19):52-54,3.基金项目
黑龙江省研究生创新科研项目（2014YJSCX-10）；浙江省温州市公益性科技计划项目（Y20150233）。 （）
